The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA (Q24307893)

Cleavage and polyadenylation specific factor 1

1 reference

Cleavage and polyadenylation specific factor 4

1 reference

Terminal uridylyl transferase 1, U6 snRNA-specific

1 reference

Cleavage and polyadenylation specific factor 3

1 reference

Cleavage and polyadenylation specific factor 2

1 reference

post-transcriptional modification

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

1 September 2024

1

Rakesh S. Laishram

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

1 September 2024

2

Richard A. Anderson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

1 September 2024

language of work or name

English

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publication date

15 December 2010

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19 November 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

full work available at URL

1 September 2024

https://europepmc.org/articles/pmc3018792?pdf=render

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Portable Document Format

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open access

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21102410/pdf/?tool=EBI

1 September 2024

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Portable Document Format

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21102410/?tool=EBI

1 September 2024

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https://europepmc.org/articles/PMC3018792

1 September 2024

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https://europepmc.org/articles/PMC3018792?pdf=render

1 September 2024

file format

Portable Document Format

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

https://doi.org/10.1038/emboj.2010.287

1 September 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21102410

1 September 2024

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29

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issue

24

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page(s)

4132-45

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cites work

Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation

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CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

19 March 2017

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Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase

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Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors

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The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation

19 March 2017

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Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA

19 March 2017

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex

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Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.

19 March 2017

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The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins

19 March 2017

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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

19 March 2017

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Formation of the 3' end of histone mRNA: getting closer to the end

19 March 2017

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3'-End processing of pre-mRNA in eukaryotes

19 March 2017

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A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates

19 March 2017

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An extensive network of coupling among gene expression machines

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Pre-mRNA processing reaches back to transcription and ahead to translation

7 April 2017

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RNA polymerase II and the integration of nuclear events

7 April 2017

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Mechanism and regulation of mRNA polyadenylation

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27 September 2017

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27 September 2017

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A history of poly A sequences: from formation to factors to function

27 September 2017

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Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.

27 September 2017

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Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and catalytic domain, homologous to the family X polymerases, and to other nucleotidyltransferases

27 September 2017

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The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location

27 September 2017

1 reference

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Preparation of capped RNA transcripts using T7 RNA polymerase

27 September 2017

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Cleavage and polyadenylation of messenger RNA precursors in vitro occurs within large and specific 3' processing complexes.

27 September 2017

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Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation

27 September 2017

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Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro

27 September 2017

1 reference

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Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Polyadenylation of mRNA: minimal substrates and a requirement for the 2' hydroxyl of the U in AAUAAA.

27 September 2017

1 reference

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Poly(A) site efficiency reflects the stability of complex formation involving the downstream element

27 September 2017

1 reference

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Analysis of the 5'-AAUAAA motif and its flanking sequence in human RNA: relevance to cDNA library sorting

27 September 2017

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Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Four factors are required for 3'-end cleavage of pre-mRNAs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Mapping the lacZ ribosome binding site by RNA footprinting

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Purification and characterization of a mammalian polyadenylate polymerase involved in the 3' end processing of messenger RNA precursors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Site-directed ribose methylation identifies 2'-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018792

Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.287

Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.287

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

21 January 2018

1 reference

12 December 2020

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1 reference

12 December 2020

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs

1 reference

12 December 2020

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus

1 reference

12 December 2020

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition

1 reference

12 December 2020

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2010.287

0 references

PMC publication ID

3018792

0 references