Structural analysis of autoinhibition in the Ras activator Son of sevenless (Q24309253)

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Dafna Bar-Sagi

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author name string

Stephen M Soisson

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Sean Boykevisch

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Shao-Song Yang

New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function

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language of work or name

English

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publication date

29 October 2004

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published in

Cell

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volume

119

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issue

3

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page(s)

393-405

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cites work

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

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Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless

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Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions

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Processing of X-ray diffraction data collected in oscillation mode

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Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

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The structural basis of the activation of Ras by Sos

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

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Untangling the ErbB signalling network

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

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RAS and RHO GTPases in G1-phase cell-cycle regulation

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Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1).

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Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

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The role of the PH domain in the signal-dependent membrane targeting of Sos.

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The complex of Arl2-GTP and PDE delta: from structure to function

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Efficient rebuilding of protein structures.

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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The guanine nucleotide-binding switch in three dimensions

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

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N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains

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Regulation of Sos activity by intramolecular interactions

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Autoinhibition of Sos by intramolecular interactions

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