SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells (Q24309440)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0097242

serum response factor

1 reference

Sterol regulatory element binding transcription factor 2

1 reference

1 reference

Myocardin

1 reference

LDL receptor related protein 1

1 reference

negative regulation of amyloid-beta clearance

1 reference

Low density lipoprotein receptor-related protein 1

1 reference

2

Rashid Deane

0 references

author name string

Robert D Bell

1

0 references

Nienwen Chow

3

0 references

Xiaochun Long

4

0 references

Abhay Sagare

5

0 references

Itender Singh

6

0 references

Jeffrey W Streb

7

0 references

Huang Guo

8

0 references

Anna Rubio

9

0 references

William Van Nostrand

10

0 references

Joseph M Miano

11

0 references

Berislav V Zlokovic

Clearance of amyloid-beta by circulating lipoprotein receptors

12

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language of work or name

English

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publication date

February 2009

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published in

Nature Cell Biology

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volume

11

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issue

2

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page(s)

143-53

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

19 March 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

19 March 2017

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Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

19 March 2017

1 reference

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Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Restricted inactivation of serum response factor to the cardiovascular system

19 March 2017

1 reference

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

19 March 2017

1 reference

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Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)

19 March 2017

1 reference

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A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context

19 March 2017

1 reference

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Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

19 March 2017

1 reference

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Neuronal migration in the murine rostral migratory stream requires serum response factor

19 March 2017

1 reference

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Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality

19 March 2017

1 reference

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The serum response factor coactivator myocardin is required for vascular smooth muscle development

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

19 March 2017

1 reference

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The blood-brain barrier in health and chronic neurodegenerative disorders

19 March 2017

1 reference

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Neurovascular regulation in the normal brain and in Alzheimer's disease

7 April 2017

1 reference

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LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

27 September 2017

1 reference

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Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms

27 September 2017

1 reference

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The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis

27 September 2017

1 reference

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Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

27 September 2017

1 reference

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Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

27 September 2017

1 reference

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Amyloid angiopathy-related vascular cognitive impairment.

27 September 2017

1 reference

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Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Serum response factor: toggling between disparate programs of gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Alzheimer disease and cerebrovascular pathology: an update

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Clearing the brain's amyloid cobwebs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Transdifferentiation of pulmonary arteriolar endothelial cells into smooth muscle-like cells regulated by myocardin involved in hypoxia-induced pulmonary vascular remodelling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Microbleed Topography, Leukoaraiosis, and Cognition in Probable Alzheimer Disease From the Sunnybrook Dementia Study

30 May 2018

1 reference

Clearance of amyloid beta-peptide from brain: transport or metabolism?

21 January 2018

1 reference

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

21 January 2018

1 reference

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

21 January 2018

1 reference

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

21 January 2018

1 reference

Coaxing the LDL receptor family into the fold.

21 January 2018

1 reference

Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice.

21 January 2018

1 reference

Silent brain infarcts and the risk of dementia and cognitive decline

21 January 2018

1 reference

Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study

21 January 2018

1 reference

Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654279

Sterol Regulatory Element-binding Protein-2 Negatively Regulates Low Density Lipoprotein Receptor-related Protein Transcription

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19098903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19098903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19098903