Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 (Q24302263)

regulation of gene expression

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Shuai Chen

1

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Laura R Bohrer

2

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Aswathy N Rai

3

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Yunqian Pan

4

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Lu Gan

5

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Xianzheng Zhou

6

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Anindya Bagchi

7

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Jeffrey A Simon

8

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Haojie Huang

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

9

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language of work or name

English

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publication date

November 2010

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published in

Nature Cell Biology

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volume

12

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issue

11

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page(s)

1108-14

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cites work

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

19 March 2017

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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

19 March 2017

1 reference

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

19 March 2017

1 reference

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

19 March 2017

1 reference

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Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

19 March 2017

1 reference

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Polycomb silencing mechanisms and the management of genomic programmes

19 March 2017

1 reference

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Control of developmental regulators by Polycomb in human embryonic stem cells

19 March 2017

1 reference

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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Polycomb complexes repress developmental regulators in murine embryonic stem cells

19 March 2017

1 reference

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Mechanisms of polycomb gene silencing: knowns and unknowns

7 April 2017

1 reference

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Polycomb silencers control cell fate, development and cancer

7 April 2017

1 reference

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Role of histone H3 lysine 27 methylation in X inactivation

7 April 2017

1 reference

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

7 April 2017

1 reference

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Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

7 April 2017

1 reference

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The polycomb group protein EZH2 is involved in progression of prostate cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

27 September 2017

1 reference

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer

27 September 2017

1 reference

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292434

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

27 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20935635

12 December 2020

inferred from PubMed ID database lookup

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

1 reference

7 January 2021

CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor

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Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells

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Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.

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Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

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A quantitative atlas of mitotic phosphorylation

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Genesis: cluster analysis of microarray data

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Identifiers

DOI

10.1038/NCB2116

1 reference

Dimensions Publication ID

1032284905

0 references

1 reference

1 reference

PubMed publication ID

20935635

1 reference