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Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2 (English)

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Proprotein convertase subtilisin/kexin type 1

1 reference

GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 1

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GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 2

1 reference

GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

S Benjannet

1

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N Rondeau

2

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L Paquet

3

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A Boudreault

4

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C Lazure

5

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M Chrétien

6

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N G Seidah

7

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language of work or name

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publication date

15 September 1993

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Biochemical Journal

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294 ( Pt 3)

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735-43

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Tyrosine sulfation is a trans-Golgi-specific protein modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

19 March 2017

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

19 March 2017

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

19 March 2017

Product review. New mammalian expression vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

7 April 2017

Molecular dissection of the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

7 April 2017

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Proteases and posttranslational processing of prohormones: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Cloning, sequencing, and secretion of Bacillusamyloliquefacienssubtillisin inBacillus subtilis

1 reference

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27 September 2017

Progress in unraveling pathways of Golgi traffic

1 reference

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27 September 2017

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas

1 reference

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27 September 2017

Protein degradation in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Mammalian subtilisins: the long-sought dibasic processing endoproteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Minireview: The New Eukaryotic Precursor Processing Proteinases

1 reference

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27 September 2017

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

The cDNA sequence of the human pro-hormone and pro-protein convertase PC1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

The prohormone and proprotein processing enzymes PC1 and PC2: structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

27 September 2017

Analysis of sequence requirements for protein tyrosine sulfation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Temperature and energy dependence of secretory protein transport in the exocrine pancreas.

1 reference

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30 May 2018

ATP-coupled transport of vesicular stomatitis virus G protein between the endoplasmic reticulum and the Golgi

1 reference

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30 May 2018

Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation.

1 reference

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30 May 2018

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells

1 reference

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30 May 2018

Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region

1 reference

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30 May 2018

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Coordinate regulation of mRNA levels of pro-opiomelanocortin and the candidate processing enzymes PC2 and PC3, but not furin, in rat pituitary intermediate lobe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Neuroanatomical and functional studies of peptide precursor-processing enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Evidence that differentiates between precursor cleavages at dibasic and Arg-X-Lys/Arg-Arg sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1 reference

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30 May 2018

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing.

1 reference

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30 May 2018

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134524

30 May 2018

Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

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Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential subcellular distribution of PC1, PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

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Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence requirements for precursor cleavage within the constitutive secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8397508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1042/BJ2940735

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