Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways (Q24312134)

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English	Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways	scientific article

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Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways (English)

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Egl-9 family hypoxia inducible factor 2

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GOA release 2020-03-11

regulation of neuron apoptotic process

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GOA release 2020-03-11

Gregg L. Semenza

6

object named as

Gregg L Semenza

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author name string

Ambreena Siddiq

1

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Leila R Aminova

2

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Carol M Troy

3

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Kyungsun Suh

4

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Zachary Messer

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Rajiv R Ratan

7

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language of work or name

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publication date

8 July 2009

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Journal of Neuroscience

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29

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27

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8828-38

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Methamphetamine toxicity and messengers of death

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A conserved family of prolyl-4-hydroxylases that modify HIF

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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6 April 2017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

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HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

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Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.

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Oxidative stress induces degradation of mitochondrial DNA

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Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

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Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury

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HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.

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Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells

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Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line

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Iron withholding: a defense against disease.

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Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

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HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

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30 May 2018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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30 May 2018

Oxidative stress induces apoptosis in embryonic cortical neurons.

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In vitro model of oxidative stress in cortical neurons

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

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https://pubmed.ncbi.nlm.nih.gov/19587290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and aberrant signaling in aging and cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587290

12 December 2020

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inferred from PubMed ID database lookup

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1779-09.2009

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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