NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint (Q24313589)

GOA release 2020-03-11

protein phosphorylation

1 reference

GOA release 2020-03-11

author

Kristian Helin

4

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author name string

Marina Melixetian

1

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Ditte Kjaersgaard Klein

2

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Claus Storgaard Sørensen

Cell-cycle checkpoints and cancer

3

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language of work or name

English

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publication date

October 2009

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published in

Nature Cell Biology

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volume

11

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issue

10

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page(s)

1247-53

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cites work

1 reference

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

20 April 2017

1 reference

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

20 April 2017

1 reference

The DNA damage response: putting checkpoints in perspective

20 April 2017

1 reference

Mammalian G1- and S-phase checkpoints in response to DNA damage

20 April 2017

2 references

20 April 2017

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

21 January 2018

1 reference

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

20 April 2017

1 reference

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

20 April 2017

1 reference

Rapid destruction of human Cdc25A in response to DNA damage

20 April 2017

1 reference

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

20 April 2017

1 reference

Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses

20 April 2017

1 reference

Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells

20 April 2017

1 reference

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

20 April 2017

1 reference

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

20 April 2017

1 reference

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

20 April 2017

1 reference

20 April 2017

1 reference

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

20 April 2017

1 reference

shRNA libraries and their use in cancer genetics

21 January 2018

1 reference

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

21 January 2018

1 reference

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

21 January 2018

1 reference

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

21 January 2018

1 reference

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

1 reference

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19734889

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19734889

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19734889