Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase (Q24324257)

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English	Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase	scientific article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

autocrine motility factor receptor

1 reference

GOA release 2020-03-11

ubiquitin-dependent ERAD pathway

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Navdar Sever

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Russell A DeBose-Boyd

3

1 reference

Europe PubMed Central

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7 January 2020

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publication date

1 September 2005

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

19

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7 January 2020

6

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PubMed publication ID

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7 January 2020

829-840

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

HMG-CoA reductase inhibitors

1 reference

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

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inferred from DOI database lookup

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Transport-Dependent Proteolysis of SREBP

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

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inferred from DOI database lookup

Regulation of the mevalonate pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

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inferred from DOI database lookup

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

1 reference

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based on heuristic

inferred from DOI database lookup

Mechanisms underlying ubiquitination

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolysis and sterol regulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2005.08.009

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based on heuristic

inferred from DOI database lookup

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.MOLCEL.2005.08.009

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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7 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16168377%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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