Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo (Q24320103)

positive regulation of protein catabolic process

GOA release 2020-03-11

1 reference

Proceedings of the National Academy of Sciences of the United States of America

GOA release 2020-03-11

1 reference

0 references

Bernard L Schneider

2

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Hilal Lashuel

series ordinal

4

object named as

Hilal A Lashuel

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author name string

Abid Oueslati

series ordinal

1

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Patrick Aebischer

series ordinal

3

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language of work or name

English

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publication date

8 October 2013

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published in

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volume

110

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issue

41

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page(s)

E3945-54

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describes a project that uses

ImageJ

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3799334/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

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27 September 2017

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Regulation of cell cycle checkpoints by polo-like kinases

27 September 2017

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Polo-like kinases and oncogenesis

27 September 2017

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

27 September 2017

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27 September 2017

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Parkinson's disease. Second of two parts

27 September 2017

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Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

27 September 2017

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Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity

30 May 2018

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Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

30 May 2018

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Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

30 May 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

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Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.

21 January 2018

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Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.

21 January 2018

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Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase

21 January 2018

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Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

21 January 2018

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Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1309991110

1 reference

ADS bibcode

2013PNAS..110E3945O

0 references

1 reference

1 reference

PubMed publication ID

23983262

1 reference