FGF21 N- and C-termini play different roles in receptor interaction and activation (Q24322074)

1

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Randy Hecht

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Jennifer Patel

3

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Jennitte Stevens

4

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Wei Wang

5

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Nessa Hawkins

6

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Shirley Steavenson

7

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Steve Smith

8

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Dwight Winters

9

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Seth Fisher

10

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Ling Cai

11

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Ed Belouski

12

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Ching Chen

13

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Mark L Michaels

14

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Yue-Sheng Li

15

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Richard Lindberg

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Minghan Wang

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Murielle Véniant

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Jing Xu

Evolution of the Fgf and Fgfr gene families

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language of work or name

English

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publication date

5 January 2009

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published in

FEBS Letters

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volume

583

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issue

1

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page(s)

19-24

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cites work

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

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Structural basis for fibroblast growth factor receptor activation

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Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

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