Mdm2 promotes the rapid degradation of p53 (Q24322597)

regulation of protein catabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Y Haupt

1

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R Maya

2

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A Kazaz

3

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M Oren

4

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language of work or name

English

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publication date

15 May 1997

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published in

Nature

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volume

387

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issue

6630

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page(s)

296-9

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cites work

Viruses and apoptosis

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7 January 2021

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

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7 January 2021

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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The mdm-2 gene is induced in response to UV light in a p53-dependent manner

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

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7 January 2021

The regulation of p53 function: Steiner Award Lecture.

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7 January 2021

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

7 January 2021