IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway (Q24337225)

Xianghuo He

11

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Gabriel N Hortobagyi

18

Gabriel N Hortobagyi

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Mien-Chie Hung

21

Mien-Chie Hung

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Chao-Kai Chou

5

Chao-Kai Chou

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Yongkun Wei

6

Yongkun Wei

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Jung-Mao Hsu

4

Jung-Mao Hsu

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Hsu-Ping Kuo

2

Hsu-Ping Kuo

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author name string

Chun-Te Chen

3

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Hui-Lung Sun

7

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Long-Yuan Li

8

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Bo Ping

9

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Wei-Chien Huang

10

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Jen-Yu Hung

12

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Chien-Chen Lai

13

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Qingqing Ding

14

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Jen-Liang Su

15

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Jer-Yen Yang

16

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Aysegul A Sahin

17

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Fuu-Jen Tsai

19

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Chang-Hai Tsai

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

20

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language of work or name

English

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publication date

10 August 2007

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published in

Cell

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volume

130

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issue

3

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page(s)

440-55

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cites work

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

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Inflammation and cancer: back to Virchow?

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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Kinase regulation in inflammatory response

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

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Akt regulates growth by directly phosphorylating Tsc2

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Dysregulation of the TSC-mTOR pathway in human disease

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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NF-kappaB: linking inflammation and immunity to cancer development and progression

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The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

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IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway

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TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

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Regulation of beta-catenin function by the IkappaB kinases

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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

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Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Upstream and downstream of mTOR

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Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase

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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

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ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells

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Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

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