Role for the adaptor protein Grb10 in the activation of Akt (Q24537512)

6 July 2017

title

Role for the adaptor protein Grb10 in the activation of Akt (English)

1 reference

6 July 2017

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Thomas Jahn

1

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6 July 2017

Petra Seipel

2

1 reference

6 July 2017

Susanne Urschel

3

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6 July 2017

Christian Peschel

4

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6 July 2017

Justus Duyster

5

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6 July 2017

language of work or name

English

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publication date

1 February 2002

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Molecular and Cellular Biology

6 July 2017

published in

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6 July 2017

volume

22

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6 July 2017

issue

4

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6 July 2017

page(s)

979-991

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Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

6 July 2017

cites work

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

24 March 2017

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A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

24 March 2017

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

24 March 2017

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24 March 2017

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Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

24 March 2017

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

24 March 2017

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Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl

24 March 2017

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Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family

24 March 2017

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Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner

24 March 2017

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Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

24 March 2017

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mGrb10 interacts with Nedd4

24 March 2017

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Regulation of cell death protease caspase-9 by phosphorylation

24 March 2017

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Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase

24 March 2017

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The SH2-containing adapter protein GRB10 interacts with BCR-ABL

24 March 2017

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

24 March 2017

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Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases

24 March 2017

1 reference

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Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

24 March 2017

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Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

24 March 2017

1 reference

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

24 March 2017

1 reference

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Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

24 March 2017

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The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

24 March 2017

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Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

24 March 2017

1 reference

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Role of translocation in the activation and function of protein kinase B

24 March 2017

1 reference

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

24 March 2017

1 reference

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

7 April 2017

1 reference

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

7 April 2017

1 reference

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

27 September 2017

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Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

27 September 2017

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Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses

27 September 2017

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Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility

27 September 2017

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Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review).

27 September 2017

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Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4.1/JEF domains and in the Grb7/10/14 adapter family

27 September 2017

1 reference

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Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site.

27 September 2017

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Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

27 September 2017

1 reference

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Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Interleukin 3-dependent survival by the Akt protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

The cloning of Grb10 reveals a new family of SH2 domain proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

The role of mGrb10alpha in insulin-like growth factor I-mediated growth

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134632

Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11809791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Grb7 Family of Signalling Proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11809791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11809791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.22.4.979-991.2002

1 reference

OpenCitations bibliographic resource ID

6 July 2017

4524971

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

6 July 2017

1 reference