Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2 (Q24538180)

20 October 2023

Azucena Esparís-Ogando

object named as

Azucena Esparís-Ogando

series ordinal

1

author given names

Azucena

author last names

Esparís-Ogando

2 references

ORCID Public Data File 2021

20 October 2023

4

Laura Yuste

Laura

Yuste

1 reference

20 October 2023

Elena Díaz-Rodríguez

2

Elena

Díaz-Rodríguez

1 reference

20 October 2023

Juan Carlos Montero

series ordinal

3

author given names

Juan Carlos

author last names

Montero

1 reference

20 October 2023

Piero Crespo

series ordinal

5

author given names

Piero

author last names

Crespo

1 reference

Molecular and Cellular Biology

20 October 2023

language of work or name

English

0 references

publication date

January 2002

0 references

published in

0 references

volume

22

0 references

issue

1

0 references

page(s)

270-85

0 references

cites work

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Primary Structure of BMK1: A New Mammalian MAP Kinase

24 March 2017

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24 March 2017

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24 March 2017

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Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

24 March 2017

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Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

24 March 2017

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MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

24 March 2017

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Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

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Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis

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24 March 2017

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Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

24 March 2017

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Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

24 March 2017

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

24 March 2017

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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Small GTPases and cell cycle regulation

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes

27 September 2017

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Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

27 September 2017

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Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases

27 September 2017

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A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

27 September 2017

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Organization and regulation of mitogen-activated protein kinase signaling pathways

27 September 2017

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Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

27 September 2017

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Mitogen-activated protein kinases: specific messages from ubiquitous messengers

27 September 2017

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Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor

27 September 2017

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Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

27 September 2017

1 reference

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ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network.

27 September 2017

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Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display

27 September 2017

1 reference

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Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

27 September 2017

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A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

27 September 2017

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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

27 September 2017

1 reference

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Bivalence of EGF-like ligands drives the ErbB signaling network

27 September 2017

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Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis

27 September 2017

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

27 September 2017

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Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit

27 September 2017

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Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

27 September 2017

1 reference

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Membrane-anchored growth factors.

27 September 2017

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RETRACTED: 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134212

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134212

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

27 September 2017

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Receptor protein-tyrosine kinases and their signal transduction pathways

27 September 2017

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The biology of erbB-2/neu/HER-2 and its role in cancer

27 September 2017

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c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134212

Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134212

TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment

27 September 2017

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Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase

27 September 2017

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Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

30 May 2018

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The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

30 May 2018

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Specificity within the EGF family/ErbB receptor family signaling network

30 May 2018

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c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

30 May 2018

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Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.

30 May 2018

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The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

29 November 2018

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Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

29 November 2018

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12 December 2020

Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium

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12 December 2020

Neu differentiation factor induces ErbB2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells

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12 December 2020

ErbB kinases and NDF signaling in human prostate cancer cells

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12 December 2020

NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways

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12 December 2020

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

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12 December 2020

10.1128/MCB.22.1.270-285.2002

Identifiers

DOI

1 reference

release_rsn7w4kevrexxkya5woalst6my

Fatcat ID

0 references

1 reference

1 reference

1 reference