Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults (Q24558984)

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English	Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults	scientific article

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Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults (English)

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Stuart A Lipton

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publication date

January 2004

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101-10

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Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

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24 March 2017

Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

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24 March 2017

The toxic effect of sodium L-glutamate on the inner layers of the retina.

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27 September 2017

NMDA receptor pathways as drug targets

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

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27 September 2017

Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Saving the nerve from glaucoma: memantine to caspaces

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

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27 September 2017

Neuroprotection in acute ischaemic stroke. Current status and future potential

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Neuroprotective therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Molecular basis of glutamate toxicity in retinal ganglion cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Emerging treatments for stroke in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Molecular mechanisms of trauma-induced neuronal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

N-methyl-D-aspartic acid receptor structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

27 September 2017

Redox modulation of the NMDA receptor by NO-related species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

30 May 2018

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

30 May 2018

Excitatory mechanisms in retinal ganglion cell death in primary open angle glaucoma (POAG).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

30 May 2018

Neuroprotective effect of memantine demonstrated in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

30 May 2018

Memantine prevents HIV coat protein-induced neuronal injury in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

30 May 2018

Calcium, free radicals and excitotoxins in neuronal apoptosis.

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https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Memantine in moderate-to-severe Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

28 November 2018

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=534915

28 November 2018

Glycine potentiates the NMDA response in cultured mouse brain neurons

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.1.1.101

21 January 2018

Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New perspectives on glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1602/NEURORX.1.1.101

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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