Oligomerization of DH domain is essential for Dbl-induced transformation (Q24551032)

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English	Oligomerization of DH domain is essential for Dbl-induced transformation	scientific article

Statements

instance of

scholarly article

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title

Oligomerization of DH domain is essential for Dbl-induced transformation (English)

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main subject

cell biology

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author name string

K Zhu

series ordinal

1

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B Debreceni

series ordinal

2

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F Bi

series ordinal

3

0 references

Y Zheng

series ordinal

4

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language of work or name

English

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publication date

January 2001

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published in

Molecular and Cellular Biology

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volume

21

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issue

2

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page(s)

425-37

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cites work

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Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

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24 March 2017

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

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Regulation of Sos activity by intramolecular interactions

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N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains

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24 March 2017

The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

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24 March 2017

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

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24 March 2017

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways

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24 March 2017

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor

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24 March 2017

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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24 March 2017

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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24 March 2017

Structure and mutagenesis of the Dbl homology domain

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24 March 2017

Rho GTPases and the actin cytoskeleton

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24 March 2017

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

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24 March 2017

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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24 March 2017

Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation

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24 March 2017

Association of the proto-oncogene product dbl with G protein betagamma subunits

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24 March 2017

GEFs: structural basis for their activation of small GTP-binding proteins

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24 March 2017

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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24 March 2017

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

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24 March 2017

The Dbl family of oncogenes

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24 March 2017

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product

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24 March 2017

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr

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24 March 2017

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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24 March 2017

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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24 March 2017

Rho GTPases and signaling networks

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24 March 2017

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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7 April 2017

Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching

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7 April 2017

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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7 April 2017

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

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27 September 2017

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

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27 September 2017

Distinct involvement of cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells

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27 September 2017

Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src.

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27 September 2017

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

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27 September 2017

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation

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27 September 2017

Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

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27 September 2017

Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

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27 September 2017

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

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27 September 2017

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

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27 September 2017

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

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27 September 2017

Control of ras activation

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27 September 2017

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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27 September 2017

A role for Rac in Tiam1-induced membrane ruffling and invasion

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27 September 2017

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

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27 September 2017

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

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27 September 2017

Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein

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27 September 2017

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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PubMed Central

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27 September 2017

Dbl family proteins

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27 September 2017

Guanine nucleotide exchange catalyzed by dbl oncogene product

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PubMed Central

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27 September 2017

Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42.

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30 May 2018

Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation

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30 May 2018

Distinct roles for DH and PH domains in the Lbc oncogene

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30 May 2018

A novel Cdc42Hs mutant induces cellular transformation

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PubMed Central

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30 May 2018

Dimerization of Cdc25p, the guanine-nucleotide exchange factor for Ras from Saccharomyces cerevisiae, and its interaction with Sdc25p.

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30 May 2018

The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting

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PubMed Central

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30 May 2018

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

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30 May 2018

Isolation of a new human oncogene from a diffuse B-cell lymphoma.

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30 May 2018

Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.

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28 November 2018

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

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PubMed Central

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28 November 2018

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Basis for Activation of ARF GTPase

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retrieved

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based on heuristic

inferred from DOI database lookup

Identifiers

DOI

10.1128/MCB.21.2.425-437.2001

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PMC publication ID

86589

0 references

PubMed publication ID

11134331

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