The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin (Q24561472)

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22 October 2019

title

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin (English)

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22 October 2019

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2

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22 October 2019

Istvan Molnar

3

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22 October 2019

Ariane König

4

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22 October 2019

author name string

T Schwecke

1

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22 October 2019

L E Khaw

5

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22 October 2019

S F Haydock

6

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22 October 2019

M Oliynyk

7

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22 October 2019

P Caffrey

8

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22 October 2019

J Cortés

9

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22 October 2019

J B Lester

10

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22 October 2019

language of work or name

English

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publication date

1 August 1995

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Proceedings of the National Academy of Sciences of the United States of America

22 October 2019

published in

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22 October 2019

volume

92

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22 October 2019

issue

17

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22 October 2019

page(s)

7839-7843

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DNA sequencing with chain-terminating inhibitors

22 October 2019

cites work

1 reference

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Basic local alignment search tool

24 March 2017

1 reference

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A comprehensive set of sequence analysis programs for the VAX

24 March 2017

1 reference

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Polyketide synthesis: prospects for hybrid antibiotics

24 March 2017

3 references

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24 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

28 November 2018

12 December 2020

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

24 March 2017

1 reference

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A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes

24 March 2017

1 reference

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Rapid and sensitive sequence comparison with FASTP and FASTA

7 April 2017

1 reference

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Graphic methods to determine the function of nucleic acid sequences

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Multidomain enzymes involved in peptide synthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

45 Tyrocidine synthetase system

27 September 2017

1 reference

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Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Ornithine cyclodeaminase from Ti plasmid C58: DNA sequence, enzyme properties and regulation of activity by arginine

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Modular organization of genes required for complex polyketide biosynthesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice

30 May 2018

1 reference

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Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

Sequence around the 159 degree region of the Bacillus subtilis genome: the pksX locus spans 33.6 kb.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41241

New antitumor substances of natural origin

28 November 2018

1 reference

12 December 2020

Rapamycin for immunosuppression in organ allografting.

1 reference

12 December 2020

Revised NMR assignments for rapamycin

1 reference

12 December 2020

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.17.7839

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7644502%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

0 references

1 reference

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22 October 2019

PubMed publication ID

7644502

1 reference