Specific small molecule inhibitors of Skp2-mediated p27 degradation (Q24596988)

1

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Arsen V Grigoryan

2

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Yunfeng Li

3

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Bing Hao

4

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Timothy J Cardozo

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

6

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language of work or name

English

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publication date

21 December 2012

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published in

Chemistry and Biology

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volume

19

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issue

12

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page(s)

1515-24

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cites work

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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

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A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1

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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

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Three different binding sites of Cks1 are required for p27-ubiquitin ligation

24 March 2017

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

24 March 2017

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

24 March 2017

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

24 March 2017

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

24 March 2017

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WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts

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27 September 2017

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Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

27 September 2017

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Structural determinants of PERK inhibitor potency and selectivity

27 September 2017

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Combination Therapy of Bortezomib with Novel Targeted Agents: An Emerging Treatment Strategy

27 September 2017

1 reference

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Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention

27 September 2017

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Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition

27 September 2017

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Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature

27 September 2017

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

27 September 2017

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Proteasome inhibitors in cancer therapy: lessons from the first decade

27 September 2017

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Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

27 September 2017

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Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

27 September 2017

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Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma.

27 September 2017

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Knockdown of S-phase kinase-associated protein-2 expression in MCF-7 inhibits cell growth and enhances the cytotoxic effects of epirubicin

27 September 2017

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Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes

27 September 2017

1 reference

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Bortezomib for the treatment of mantle cell lymphoma

27 September 2017

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E3 ubiquitin ligases as cancer targets and biomarkers

27 September 2017

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Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Druggability of SCF ubiquitin ligase-protein interfaces

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Down-regulation of Skp2 is correlated with p27-associated cell cycle arrest induced by phenylacetate in human prostate cancer cells.

27 September 2017

1 reference

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Comprehensive identification of "druggable" protein ligand binding sites.

27 September 2017

1 reference

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

27 September 2017

1 reference

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Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

27 September 2017

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Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

27 September 2017

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

27 September 2017

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High-throughput docking for lead generation

27 September 2017

1 reference

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

27 September 2017

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Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival

27 September 2017

1 reference

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Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

27 September 2017

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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

27 September 2017

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Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi.

30 May 2018

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Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Molecular and biochemical characterization of the Skp2-Cks1 binding interface

28 November 2018

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Approval summary for bortezomib for injection in the treatment of multiple myeloma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Skp2-mediated degradation of p27 regulates progression into mitosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530153

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

28 November 2018

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Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23261596

12 December 2020

inferred from PubMed ID database lookup

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23261596

12 December 2020

inferred from PubMed ID database lookup

Expression of Skp2 and p27KIP1 in naevi and malignant melanoma of the skin and its relation to clinical outcome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23261596

12 December 2020

inferred from PubMed ID database lookup

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CHEMBIOL.2012.09.015

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.09.015

1 reference

release_olrloxalerekrktjevuelolbe4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/olrloxalerekrktjevuelolbe4

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

23261596

1 reference