RANK is essential for osteoclast and lymph node development (Q24598872)

GOA release 2020-03-11

author name string

W C Dougall

1

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M Glaccum

2

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K Charrier

3

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K Rohrbach

4

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K Brasel

5

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T De Smedt

6

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E Daro

7

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J Smith

8

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M E Tometsko

9

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C R Maliszewski

10

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A Armstrong

11

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V Shen

12

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S Bain

13

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D Cosman

14

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D Anderson

15

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P J Morrissey

16

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J J Peschon

17

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J Schuh

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

18

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language of work or name

English

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publication date

15 September 1999

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published in

Genes & Development

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volume

13

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issue

18

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page(s)

2412-24

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cites work

1 reference

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

24 March 2017

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

24 March 2017

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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

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Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

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RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis

24 March 2017

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The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

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Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

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Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells

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Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone

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Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

27 September 2017

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27 September 2017

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Modulation of osteoclast differentiation

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Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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Identifiers

DOI

10.1101/GAD.13.18.2412

1 reference

1 reference

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PubMed publication ID

10500098

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