Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 (Q24600230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649508%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 (English)

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12 November 2019

3

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12 November 2019

author name string

H Niwa

series ordinal

1

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12 November 2019

T Burdon

series ordinal

2

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12 November 2019

A Smith

series ordinal

4

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12 November 2019

language of work or name

English

0 references

publication date

1 July 1998

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12 November 2019

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12 November 2019

volume

12

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12 November 2019

issue

13

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12 November 2019

page(s)

2048-2060

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

12 November 2019

cites work

1 reference

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Activation and association of Stat3 with Src in v-Src-transformed cell lines

7 April 2017

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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

7 April 2017

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Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

7 April 2017

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Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130

7 April 2017

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Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

7 April 2017

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Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

7 April 2017

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Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

7 April 2017

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Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells

7 April 2017

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Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

7 April 2017

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7 April 2017

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Molecular cloning and expression of an IL-6 signal transducer, gp130

7 April 2017

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Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

7 April 2017

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

7 April 2017

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

7 April 2017

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7 April 2017

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Establishment in culture of pluripotential cells from mouse embryos

27 September 2017

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

7 April 2017

1 reference

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Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction

7 April 2017

1 reference

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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

7 April 2017

1 reference

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

7 April 2017

1 reference

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Cytokine signal transduction

7 April 2017

1 reference

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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

7 April 2017

1 reference

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

7 April 2017

1 reference

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

7 April 2017

1 reference

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

7 April 2017

1 reference

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Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

7 April 2017

1 reference

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Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

7 April 2017

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Oncostatin M binds the high-affinity leukemia inhibitory factor receptor

7 April 2017

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Expression cloning of a receptor for murine granulocyte colony-stimulating factor

7 April 2017

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

7 April 2017

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

7 April 2017

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Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor.

7 April 2017

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Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region.

27 September 2017

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Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells

27 September 2017

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Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells

27 September 2017

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The origin and efficient derivation of embryonic stem cells in the mouse

27 September 2017

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A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

27 September 2017

1 reference

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Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation

27 September 2017

1 reference

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STATs: signal transducers and activators of transcription

27 September 2017

1 reference

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Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

27 September 2017

1 reference

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Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

27 September 2017

1 reference

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Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells

27 September 2017

1 reference

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Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells

27 September 2017

1 reference

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Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

27 September 2017

1 reference

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Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice

27 September 2017

1 reference

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Alkaline Phosphatase Activity in Mouse Teratoma

27 September 2017

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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

27 September 2017

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The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer

27 September 2017

1 reference

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Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways

27 September 2017

1 reference

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Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

27 September 2017

1 reference

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The LIF response element of the alpha 2 macroglobulin gene confers LIF-induced transcriptional activation in embryonal stem cells

27 September 2017

1 reference

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Oncostatin M (OSM) inhibits the differentiation of pluripotent embryonic stem cells in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316954

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells

27 September 2017

1 reference

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The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor

30 May 2018

1 reference

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Purification and characterization of soluble human IL-6 receptor expressed in CHO cells

30 May 2018

1 reference

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Expression of v-src induces aberrant development and twinning in chimaeric mice

30 May 2018

1 reference

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Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations

30 May 2018

1 reference

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Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway

30 May 2018

1 reference

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Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.

28 November 2018

1 reference

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Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy

28 November 2018

1 reference

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Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor

28 November 2018

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12 December 2020

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

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12 December 2020

Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse fibroblast L929 cells

1 reference

12 December 2020

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

1 reference

12 December 2020

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

1 reference

12 December 2020

Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells

1 reference

12 December 2020

Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor

1 reference

12 December 2020

Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor

1 reference

12 December 2020

Essential function of LIF receptor in motor neurons

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12 December 2020

Identifiers

DOI

10.1101/GAD.12.13.2048

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649508%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649508%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

9649508

2 references