A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans (Q24603590)

GOA release 2020-03-11

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5

G Ruvkun

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author name string

S Paradis

1

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M Ailion

2

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A Toker

3

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J H Thomas

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

4

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language of work or name

English

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publication date

1 June 1999

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published in

Genes & Development

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volume

13

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issue

11

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page(s)

1438-52

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cites work

1 reference

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7 April 2017

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

7 April 2017

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Phosphorylation and activation of p70s6k by PDK1

7 April 2017

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

7 April 2017

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Mechanism of activation of protein kinase B by insulin and IGF-1

7 April 2017

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

7 April 2017

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Aging and resistance to oxidative damage in Caenorhabditis elegans

7 April 2017

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The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

7 April 2017

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daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans

7 April 2017

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

7 April 2017

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

7 April 2017

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A C. elegans mutant that lives twice as long as wild type

7 April 2017

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Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences

7 April 2017

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

7 April 2017

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Green fluorescent protein as a marker for gene expression

7 April 2017

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

7 April 2017

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

7 April 2017

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Signalling through the lipid products of phosphoinositide-3-OH kinase

7 April 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 April 2017

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A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

7 April 2017

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The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

7 April 2017

1 reference

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Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

7 April 2017

1 reference

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

7 April 2017

1 reference

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Role of translocation in the activation and function of protein kinase B

7 April 2017

1 reference

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

7 April 2017

1 reference

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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

7 April 2017

1 reference

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

7 April 2017

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 April 2017

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Genes that regulate both development and longevity in Caenorhabditis elegans

7 April 2017

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

7 April 2017

1 reference

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Oxidative stress, caloric restriction, and aging

7 April 2017

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p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

7 April 2017

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Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Interacting genes in nematode dauer larva formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Control of C. elegans larval development by neuronal expression of a TGF-beta homolog

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

Insulin signal transduction through protein kinase cascades

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316759

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10364160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Control of larval development by chemosensory neurons in Caenorhabditis elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10364160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.13.11.1438

1 reference

1 reference

1 reference

PubMed publication ID

10364160

1 reference