Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH (Q24603767)

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English	Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH	scientific article

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instance of

scholarly article

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title

Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH (English)

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main subject

cell biology

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multiple myeloma

1 reference

based on heuristic

inferred from title

cell death

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based on heuristic

inferred from title

author

Donald Kufe

series ordinal

3

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author name string

Li Yin

series ordinal

1

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Michio Kosugi

series ordinal

2

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language of work or name

English

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publication date

19 January 2012

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published in

Blood

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volume

119

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issue

3

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page(s)

810-6

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cites work

Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death

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Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin

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MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

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DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7

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Importance of glucose-6-phosphate dehydrogenase activity in cell death

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MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells

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Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS

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Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function

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MUC1 oncoprotein is a druggable target in human prostate cancer cells

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HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells

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Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells

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MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation

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MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells

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The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage

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The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop

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Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.

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MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling

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27 September 2017

Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia

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Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species.

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Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

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27 September 2017

Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis

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Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

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Human DF3/MUC1 carcinoma-associated protein functions as an oncogene

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Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL.

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Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone.

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Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress

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Interleukin 10 abolishes the growth inhibitory effects of all-trans retinoic acid on human myeloma cells

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Epithelial mucin-1 (MUC1) expression and MA5 anti-MUC1 monoclonal antibody targeting in multiple myeloma

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MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress

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Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient

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MUC1 (EMA) expressing plasma cells in bone marrow infiltrated by plasma cell myeloma

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MUC1 expression in plasmacytoma

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Identifiers

DOI

10.1182/BLOOD-2011-07-369686

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PMC publication ID

3265204

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PubMed publication ID

22117045

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ResearchGate publication ID

51830327

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