The gastric HK-ATPase: structure, function, and inhibition (Q24612375)

The gastric H,K ATPase as a drug target: past, present, and future

Europe PubMed Central

title

The gastric HK-ATPase: structure, function, and inhibition (English)

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2

Keith Munson

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author name string

Jai Moo Shin

series ordinal

1

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Olga Vagin

series ordinal

3

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George Sachs

series ordinal

4

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language of work or name

English

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publication date

January 2009

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published in

Pfluegers Archiv

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volume

457

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issue

3

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page(s)

609-22

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cites work

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Analysis of the gastric H,K ATPase for ion pathways and inhibitor binding sites

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Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands

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Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo

27 September 2017

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Inhibitor and ion binding sites on the gastric H,K-ATPase

27 September 2017

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Use of the H,K-ATPase beta subunit to identify multiple sorting pathways for plasma membrane delivery in polarized cells.

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A carboxy-terminus motif of HKalpha2 is necessary for assembly and function

27 September 2017

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The H,K-ATPase beta subunit as a model to study the role of N-glycosylation in membrane trafficking and apical sorting

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27 September 2017

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SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain

27 September 2017

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Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase.

27 September 2017

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27 September 2017

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Pharmacodynamic modeling of pantoprazole's irreversible effect on gastric acid secretion in humans and rats

27 September 2017

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The site of action of pantoprazole in the gastric H+/K(+)-ATPase

27 September 2017

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The continuing development of gastric acid pump inhibitors

27 September 2017

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Molecular cloning and structural analysis of canine gastric H+,K(+)-ATPase

27 September 2017

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Identification of a region of the H,K-ATPase alpha subunit associated with the beta subunit.

27 September 2017

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Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

27 September 2017

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Correlation of Parietal Cell Structure and Function

27 September 2017

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The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump).

27 September 2017

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Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor

27 September 2017

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cDNA cloning and membrane topology of the rabbit gastric H+/K+-ATPase α-subunit

27 September 2017

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A nonelectrogenic H+ pump in plasma membranes of hog stomach

27 September 2017

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Definition and antagonism of histamine H 2 -receptors

27 September 2017

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Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079481

cDNA cloning and sequence determination of pig gastric (H+ + K+)-ATPase

30 May 2018

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Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines.

30 May 2018

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Evidence for a relationship between activity and the tetraprotomeric assembly of solubilized pig gastric H/K-ATPase

30 May 2018

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The conformation of H,K-ATPase determines the nucleoside triphosphate (NTP) selectivity for active proton transport

21 January 2018

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Fluorometric measurements of intermolecular distances between the alpha- and beta-subunits of the Na+/K+-ATPase

28 November 2018

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Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase

28 November 2018

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The cryofixation of isolated rat gastric mucosa provides new insights into the functional transformation of gastric parietal cells: an in vitro experimental model study

28 November 2018

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Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase.

28 November 2018

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Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.

28 November 2018

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Differences in binding properties of two proton pump inhibitors on the gastric H+,K+-ATPase in vivo

28 November 2018

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Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors

28 November 2018

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The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump

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Molecular modeling of SCH28080 binding to the gastric H,K-ATPase and MgATP interactions with SERCA- and Na,K-ATPases

28 November 2018

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Crystal structures of Ca2+-ATPase in various physiological states.

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Electrogenicity of Na,K- and H,K-ATPase activity and presence of a positively charged amino acid in the fifth transmembrane segment.

28 November 2018

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Restoration of acid secretion following treatment with proton pump inhibitors

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ATP1AL1, a member of the non-gastric H,K-ATPase family, functions as a sodium pump.

28 November 2018

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Regions of association between the alpha and the beta subunit of the gastric H,K-ATPase.

28 November 2018

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Irreversible inactivation of rat gastric (H+-K+)-ATPase in vivo by omeprazole

28 November 2018

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The gastric [H,K]ATPase:H+/ATP stoichiometry

28 November 2018

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12 December 2020

Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazole

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12 December 2020

K+ and Cl- conductances in the apical membrane from secreting oxyntic cells are concurrently inhibited by divalent cations

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12 December 2020

The relationship between gastric acid secretion and gastric H+,K+-ATPase activity

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12 December 2020

H+ transport by reconstituted gastric (H+ + K+)-ATPase

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12 December 2020

SCH28080 prevents omeprazole inhibition of the gastric H+/K+-ATPase

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12 December 2020

Membrane topology and omeprazole labeling of the gastric H+,K(+)-adenosinetriphosphatase

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12 December 2020

Turnover of the gastric H+,K(+)-adenosine triphosphatase alpha subunit and its effect on inhibition of rat gastric acid secretion

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Comparative pharmacokinetic/pharmacodynamic analysis of proton pump inhibitors omeprazole, lansoprazole and pantoprazole, in humans

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12 December 2020

Pharmacokinetics of a new reversible proton pump inhibitor, YH1885, after intravenous and oral administrations to rats and dogs: hepatic first-pass effect in rats

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12 December 2020

Association of renal Na,K-ATPase alpha-subunit with the beta- and gamma-subunits based on cryoelectron microscopy

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12 December 2020

Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526)

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12 December 2020

Pantoprazole versus omeprazole: influence on meal-stimulated gastric acid secretion

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12 December 2020

Cellular distribution of parchorin, a chloride intracellular channel-related protein, in various tissues

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12 December 2020

H+/ATP stoichiometry for the gastric (K++H+)-ATPase

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12 December 2020

10.1007/S00424-008-0495-4

Identifiers

DOI

1 reference

Dimensions Publication ID

1046856644

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1 reference

1 reference

PubMed publication ID

18536934

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