Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease (Q24627125)

Future Medicinal Chemistry

Europe PubMed Central

title

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease (English)

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1 reference

Michael Voronkov

1

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Steven P Braithwaite

series ordinal

2

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Jeffry B Stock

series ordinal

3

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language of work or name

English

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publication date

May 2011

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published in

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Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

volume

3

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issue

7

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page(s)

821-33

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cites work

1 reference

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Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

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27 September 2017

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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

27 September 2017

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Open-label, phase I dose-escalation study of sodium selenate, a novel activator of PP2A, in patients with castration-resistant prostate cancer.

27 September 2017

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Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

30 May 2018

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Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

30 May 2018

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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

30 May 2018

1 reference

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Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds

30 May 2018

1 reference

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Stimulation of phosphorylase phosphatase activity of protein phosphatase 2A1 by protamine is ionic strength dependent and involves interaction of protamine with both substrate and enzyme.

30 May 2018

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Ceramide activates heterotrimeric protein phosphatase 2A.

30 May 2018

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30 May 2018

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21 January 2018

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Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

21 January 2018

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Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

21 January 2018

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21 January 2018

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APP processing is regulated by cytoplasmic phosphorylation

21 January 2018

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21 January 2018

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A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function

21 January 2018

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Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation

28 November 2018

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The protein phosphatases involved in cellular regulation. 1. Modulation of protein phosphatases-1 and 2A by histone H1, protamine, polylysine and heparin

28 November 2018

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12 December 2020

Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis

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12 December 2020

Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit

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12 December 2020

Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase

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12 December 2020

Purification and Characterization of a Novel Xylulose 5-Phosphate-activated Protein Phosphatase Catalyzing Dephosphorylation of Fructose-6-phosphate,2-kinase:Fructose-2,6-bisphosphatase

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12 December 2020

Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

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12 December 2020

Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion

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12 December 2020

Sealing effects of (-)-epigallocatechin gallate on protein kinase C and protein phosphatase 2A

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12 December 2020

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

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12 December 2020

Pathological tau: a loss of normal function or a gain in toxicity?

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12 December 2020

Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition

1 reference

12 December 2020

Identifiers

DOI

10.4155/FMC.11.47

1 reference

1 reference

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PubMed publication ID

21644827

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