Therapeutic potential of perineural invasion, hypoxia and desmoplasia in pancreatic cancer (Q24621214)

2

0 references

Qinhong Xu

3

0 references

Jianjun Lei

4

0 references

Xuqi Li

5

0 references

Zheng Wang

6

0 references

Erxi Wu

Current Pharmaceutical Design

7

0 references

language of work or name

English

0 references

publication date

2012

0 references

published in

0 references

volume

18

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issue

17

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page(s)

2395-403

0 references

cites work

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Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1α under normoxic condition

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27 September 2017

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Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

27 September 2017

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Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells

27 September 2017

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27 September 2017

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Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice

27 September 2017

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Perineural invasion in cancer: a review of the literature.

27 September 2017

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Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer

27 September 2017

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27 September 2017

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Synuclein-gamma is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer

27 September 2017

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The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma

27 September 2017

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Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance.

27 September 2017

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Cancer of the pancreas: are we making progress? A review of studies in the US Oncology Research Network

27 September 2017

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PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells

27 September 2017

1 reference

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Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells

27 September 2017

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Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells

27 September 2017

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27 September 2017

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Pancreatic stellate cells--role in pancreas cancer

27 September 2017

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Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

27 September 2017

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MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion

27 September 2017

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Tumor-stroma interactions in pancreatic ductal adenocarcinoma

27 September 2017

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Manipulation of the nerve growth factor network in prostate cancer

27 September 2017

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Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis

27 September 2017

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Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach.

27 September 2017

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Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis.

27 September 2017

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The neurotrophic factor artemin promotes pancreatic cancer invasion

27 September 2017

1 reference

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Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma

27 September 2017

1 reference

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Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells

27 September 2017

1 reference

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The neurotrophic receptor TrkB: a drug target in anti-cancer therapy?

27 September 2017

1 reference

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Epidemiology and risk factors for pancreatic cancer.

27 September 2017

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Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells

27 September 2017

1 reference

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Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature

27 September 2017

1 reference

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Pancreatic cancer: basic and clinical aspects

27 September 2017

1 reference

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Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

27 September 2017

1 reference

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Mechanisms of pancreatic fibrosis.

27 September 2017

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Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression

27 September 2017

1 reference

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Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells

27 September 2017

1 reference

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Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

27 September 2017

1 reference

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The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma

27 September 2017

1 reference

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Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway

27 September 2017

1 reference

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Microvascular development: learning from pancreatic islets

27 September 2017

1 reference

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Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells

27 September 2017

1 reference

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Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

27 September 2017

1 reference

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Tumor hypoxia: a target for selective cancer therapy

27 September 2017

1 reference

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Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Neural invasion in pancreatic carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Cell migration: a novel aspect of pancreatic stellate cell biology

27 September 2017

1 reference

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TGFbeta-induced fibrogenesis of the pancreas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Tumor deposition of laminin-5 and the relationship with perineural invasion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Experimental implication of celiac ganglionotropic invasion of pancreatic-cancer cells bearing c-ret proto-oncogene with reference to glial-cell-line-derived neurotrophic factor (GDNF).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.

27 September 2017

1 reference

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Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

30 May 2018

1 reference

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Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis

30 May 2018

1 reference

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Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway.

30 May 2018

1 reference

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Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis

30 May 2018

1 reference

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Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer

30 May 2018

1 reference

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Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

30 May 2018

1 reference

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Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein.

30 May 2018

1 reference

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Specific Targeting of Tumor Endothelial Cells by a Shiga-like Toxin-Vascular Endothelial Growth Factor Fusion Protein as a Novel Treatment Strategy for Pancreatic Cancer

30 May 2018

1 reference

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Effects of ethanol and its metabolites on human pancreatic stellate cells

28 November 2018

1 reference

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Fibrinogen induces cytokine and collagen production in pancreatic stellate cells

28 November 2018

1 reference

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Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

28 November 2018

1 reference

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The nature of neural invasion by pancreatic cancer.

28 November 2018

1 reference

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Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

28 November 2018

1 reference

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Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway

28 November 2018

1 reference

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Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats

28 November 2018

1 reference

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Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

28 November 2018

1 reference

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A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells

28 November 2018

1 reference

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Stellate Cell Activation in Alcoholic Pancreatitis

28 November 2018

1 reference

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Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid

28 November 2018

1 reference

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Neural Invasion in the Staging of Pancreatic Cancer

28 November 2018

1 reference

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Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats

28 November 2018

1 reference

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Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414721

Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

28 November 2018

1 reference

12 December 2020

Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis

1 reference

12 December 2020

The epidemiology of pancreatic cancer in the United States: changes below the surface

1 reference

12 December 2020

Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells

1 reference

12 December 2020

Nerve growth factor is a potential therapeutic target in breast cancer

1 reference

12 December 2020

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

1 reference

12 December 2020

Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteins

1 reference

12 December 2020

Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions

1 reference

12 December 2020

Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus

1 reference

12 December 2020

Clinicopathological study on neural invasion to the extrapancreatic nerve plexus in pancreatic cancer

1 reference

12 December 2020

Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer

1 reference

12 December 2020

Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis

1 reference

12 December 2020

Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer

1 reference

12 December 2020

Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion

1 reference

12 December 2020

Protease-Activated Receptor-2-Mediated Proliferation and Collagen Production of Rat Pancreatic Stellate Cells

1 reference

12 December 2020

10.2174/13816128112092395

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

22372500

1 reference