Pathway of ATP hydrolysis by monomeric kinesin Eg5 (Q24644762)

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English	Pathway of ATP hydrolysis by monomeric kinesin Eg5	scientific article

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title

Pathway of ATP hydrolysis by monomeric kinesin Eg5 (English)

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author name string

Jared C Cochran

series ordinal

1

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Troy C Krzysiak

series ordinal

2

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Susan P Gilbert

series ordinal

3

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language of work or name

English

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publication date

10 October 2006

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published in

Biochemistry

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volume

45

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issue

40

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page(s)

12334-44

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cites work

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

1 reference

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PubMed Central

reference URL

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7 April 2017

Monastrol inhibition of the mitotic kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

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7 April 2017

Mechanistic analysis of the mitotic kinesin Eg5.

1 reference

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PubMed Central

reference URL

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7 April 2017

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

A bipolar kinesin

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Inhibition of a mitotic motor protein: where, how, and conformational consequences

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Switch-based mechanism of kinesin motors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

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stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

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stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

The way things move: looking under the hood of molecular motor proteins

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Mitotic spindle organization by a plus-end-directed microtubule motor

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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7 April 2017

Kinesin-related proteins required for structural integrity of the mitotic spindle

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

7 April 2017

A structural model for monastrol inhibition of dimeric kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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27 September 2017

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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27 September 2017

Inhibitors of kinesin motor proteins--research and clinical progress

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Mitotic kinesins: prospects for antimitotic drug discovery.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Antitumor activity of a kinesin inhibitor

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Kinesin's second step

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

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27 September 2017

A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

What kinesin does at roadblocks: the coordination mechanism for molecular walking

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Kinetics: a tool to study molecular motors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Kinetics and motility of the Eg5 microtubule motor

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Purification and characterization of two monomeric kinesin constructs

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Pathway of processive ATP hydrolysis by kinesin.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

Kinesin ATPase: rate-limiting ADP release

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

27 September 2017

The design plan of kinesin motors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

30 May 2018

A kinetic study of the kinesin ATPase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

30 May 2018

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

A pathway of structural changes produced by monastrol binding to Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Docking and rolling, a model of how the mitotic motor Eg5 works

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

The kinesin family member BimC contains a second microtubule binding region attached to the N terminus of the motor domain

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

ATP reorients the neck linker of kinesin in two sequential steps

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Kinetic mechanism of a monomeric kinesin construct.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2288585

retrieved

28 November 2018

Nucleotide-free kinesin hydrolyzes ATP with burst kinetics

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monomeric kinesin head domains hydrolyze multiple ATP molecules before release from a microtubule

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic evidence for low chemical processivity in ncd and Eg5

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic mechanism of monomeric non-claret disjunctional protein (Ncd) ATPase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathway of ATP hydrolysis by monomeric and dimeric kinesin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Equilibrium binding studies of non-claret disjunctional protein (Ncd) reveal cooperative interactions between the motor domains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moving a microtubule may require two heads: a kinetic investigation of monomeric Ncd

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17014086

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/BI0608562

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1410895

OpenCitations bibliographic resource ID

1410895

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1410895

PMC publication ID

2288585

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1410895

PubMed publication ID

17014086

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1410895

ResearchGate publication ID

6781163

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