Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 (Q24646482)

Pre B cell leukemia homeobox 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Pbx/knotted 1 homeobox

1 reference

GOA release 2020-03-11

author name string

P S Knoepfler

1

0 references

K R Calvo

2

0 references

H Chen

3

0 references

S E Antonarakis

4

0 references

M P Kamps

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

0 references

publication date

23 December 1997

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published in

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volume

94

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issue

26

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page(s)

14553-8

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cites work

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Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

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A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif

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Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia

7 April 2017

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Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

7 April 2017

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Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice

7 April 2017

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PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1

7 April 2017

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Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

7 April 2017

1 reference

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A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

7 April 2017

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Homeobox genes and axial patterning

7 April 2017

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The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

7 April 2017

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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

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7 April 2017

https://pubmed.ncbi.nlm.nih.gov/9405651

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

1 reference

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Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

27 September 2017

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Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper-like coiled-coil motifs.

27 September 2017

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27 September 2017

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E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

27 September 2017

1 reference

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A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1.

27 September 2017

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Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction

27 September 2017

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Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

27 September 2017

1 reference

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Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

27 September 2017

1 reference

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The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Homeobox proteins as sequence-specific transcription factors

27 September 2017

1 reference

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Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

30 May 2018

1 reference

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Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.26.14553

extradenticle raises the DNA binding specificity of homeotic selector gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.26.14553

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.26.14553

Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.26.14553

Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25052

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9405651

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9405651