Computational design of Candida boidinii xylose reductase for altered cofactor specificity (Q24647217)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693930%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Computational design of Candida boidinii xylose reductase for altered cofactor specificity (English)

1 reference

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5 February 2020

Candida boidinii

1 reference

1 reference

1

1 reference

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5 February 2020

Costas D. Maranas

6

1 reference

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5 February 2020

author name string

Hossein Fazelinia

2

1 reference

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5 February 2020

Jonathan W Chin

3

1 reference

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5 February 2020

Robert J Pantazes

4

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5 February 2020

Patrick C Cirino

5

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5 February 2020

language of work or name

English

0 references

publication date

1 October 2009

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5 February 2020

1 reference

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5 February 2020

volume

18

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5 February 2020

issue

10

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5 February 2020

page(s)

2125-2138

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De novo computational design of retro-aldol enzymes

5 February 2020

cites work

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Cloning and Characterization of the xyl1 Gene, Encoding an NADH-Preferring Xylose Reductase from Candida parapsilosis , and Its Functional Expression in Candida tropicalis

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The Protein Data Bank

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7 April 2017

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7 April 2017

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7 April 2017

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Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases

7 April 2017

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The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis

7 April 2017

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Probing the determinants of coenzyme specificity in ferredoxin-NADP+ reductase by site-directed mutagenesis

7 April 2017

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Switch of coenzyme specificity of p-hydroxybenzoate hydroxylase

7 April 2017

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De novo protein design: fully automated sequence selection

7 April 2017

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Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme

7 April 2017

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7 April 2017

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7 April 2017

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Mechanism of human aldehyde reductase: characterization of the active site pocket

7 April 2017

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Determinants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of glutamine 362

7 April 2017

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Backbone-dependent rotamer library for proteins. Application to side-chain prediction

7 April 2017

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Directed enzyme evolution: climbing fitness peaks one amino acid at a time

7 April 2017

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AraC regulatory protein mutants with altered effector specificity

27 September 2017

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Altering coenzyme specificity of Pichia stipitis xylose reductase by the semi-rational approach CASTing

27 September 2017

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Extending Iterative Protein Redesign and Optimization (IPRO) in protein library design for ligand specificity

27 September 2017

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Direct demonstration of an adaptive constraint

27 September 2017

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Catalytic mechanism and substrate selectivity of aldo-keto reductases: insights from structure-function studies of Candida tenuis xylose reductase

27 September 2017

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Crystal structure of NADP(H)-dependent 1,5-anhydro-D-fructose reductase from Sinorhizobium morelense at 2.2 A resolution: construction of a NADH-accepting mutant and its application in rare sugar synthesis

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Xylose utilisation: cloning and characterisation of the Xylose reductase from Candida tenuis

27 September 2017

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Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases

27 September 2017

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27 September 2017

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Reversal of the nucleotide specificity of ketol acid reductoisomerase by site-directed mutagenesis identifies the NADPH binding site

27 September 2017

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Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase

27 September 2017

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A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity

27 September 2017

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D175 discriminates between NADH and NADPH in the coenzyme binding site of Lactobacillus delbrueckii subsp. bulgaricus D-lactate dehydrogenase

27 September 2017

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Conformational analysis of the backbone-dependent rotamer preferences of protein sidechains

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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30 May 2018

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Engineering Candida tenuis Xylose reductase for improved utilization of NADH: antagonistic effects of multiple side chain replacements and performance of site-directed mutants under simulated in vivo conditions

30 May 2018

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30 May 2018

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30 May 2018

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The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography

30 May 2018

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Molecular Characterization of a Gene for Aldose Reductase ( CbXYL1) from Candida boidinii and Its Expression in Saccharomyces cerevisiae

30 May 2018

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30 May 2018

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Determinants of coenzyme specificity in glyceraldehyde-3-phosphate dehydrogenase: role of the acidic residue in the fingerprint region of the nucleotide binding fold.

30 May 2018

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Conversion of the coenzyme specificity of isocitrate dehydrogenase by module replacement

30 May 2018

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Analysis of NADPH supply during xylitol production by engineered Escherichia coli

21 January 2018

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28 November 2018

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Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase

28 November 2018

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Engineering Escherichia coli for xylitol production from glucose-xylose mixtures

28 November 2018

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Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity

28 November 2018

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28 November 2018

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Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+.

28 November 2018

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Complete reversal of coenzyme specificity of xylitol dehydrogenase and increase of thermostability by the introduction of structural zinc

28 November 2018

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Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design

28 November 2018

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Engineering and Characterization of a NADPH-Utilizing Cytochrome b5 Reductase

28 November 2018

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28 November 2018

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28 November 2018

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Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in Vivo

28 November 2018

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Optimizing an artificial metabolic pathway: engineering the cofactor specificity of Corynebacterium 2,5-diketo-D-gluconic acid reductase for use in vitamin C biosynthesis

28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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12 December 2020

Local interactions as a structure determinant for protein molecules: II

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Hydrophobicity and structural classes in proteins

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12 December 2020

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Mutational analysis of the role of the conserved lysine-270 in the Pichia stipitis xylose reductase

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Protein engineering and the development of generic biosensors

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CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

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7 January 2021

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Novel generalized Born methods

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7 January 2021

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Equation of State Calculations by Fast Computing Machines

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/PRO.227

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693930%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693930%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

19693930

2 references