Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways (Q24647626)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

1 reference

title

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

0 references

2

1 reference

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25 January 2020

author name string

Brenda A Schulman

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

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publication date

8 April 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Molecular Cell Biology

25 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

10

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25 January 2020

issue

5

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25 January 2020

page(s)

319-331

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A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

25 January 2020

cites work

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Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy

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E1-L2 activates both ubiquitin and FAT10

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Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme

7 April 2017

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7 April 2017

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Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1

7 April 2017

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7 April 2017

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7 April 2017

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The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

7 April 2017

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A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

7 April 2017

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Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer

7 April 2017

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Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

7 April 2017

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The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

7 April 2017

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The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

7 April 2017

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Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

7 April 2017

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Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1

7 April 2017

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Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes

7 April 2017

1 reference

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Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1 † ‡

7 April 2017

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The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins

7 April 2017

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Crystal structure of Ufc1, the Ufm1-conjugating enzyme

7 April 2017

1 reference

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The Intrinsic Affinity between E2 and the Cys Domain of E1 in Ubiquitin-like Modifications

7 April 2017

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The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation

7 April 2017

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Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity

7 April 2017

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The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

7 April 2017

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Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

7 April 2017

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Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex

7 April 2017

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Solution structure of ThiS and implications for the evolutionary roots of ubiquitin

7 April 2017

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7 April 2017

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7 April 2017

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Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

7 April 2017

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7 April 2017

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7 April 2017

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Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems

7 April 2017

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The basis for selective E1-E2 interactions in the ISG15 conjugation system

7 April 2017

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7 April 2017

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A ubiquitin-like system mediates protein lipidation

7 April 2017

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A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes

7 April 2017

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Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy

7 April 2017

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A protein conjugation system essential for autophagy

7 April 2017

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A novel protein modification pathway related to the ubiquitin system

7 April 2017

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The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

7 April 2017

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7 April 2017

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UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme

7 April 2017

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7 April 2017

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7 April 2017

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Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

7 April 2017

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7 April 2017

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7 April 2017

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E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

7 April 2017

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Crystal structure of a fragment of mouse ubiquitin-activating enzyme

7 April 2017

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Polyubiquitin chains: polymeric protein signals

7 April 2017

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A mechanism for inhibiting the SUMO pathway

7 April 2017

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Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation

7 April 2017

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Biochemistry. All in the ubiquitin family

7 April 2017

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Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex

7 April 2017

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The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis

7 April 2017

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Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

7 April 2017

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Ubiquitin-binding domains

7 April 2017

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Ubiquitin-binding domains

7 April 2017

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Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

7 April 2017

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Ubiquitin: structures, functions, mechanisms

7 April 2017

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Evolution and function of ubiquitin-like protein-conjugation systems

7 April 2017

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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

10 May 2017

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Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

27 September 2017

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Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

27 September 2017

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E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development

27 September 2017

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Cancer proliferation gene discovery through functional genomics.

27 September 2017

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The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously

27 September 2017

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Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

27 September 2017

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Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins

27 September 2017

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UBE1L2, a novel E1 enzyme specific for ubiquitin

27 September 2017

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A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome

27 September 2017

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

27 September 2017

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Structural complexity in ubiquitin recognition.

27 September 2017

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Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

27 September 2017

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Lingering mysteries of ubiquitin-chain assembly

27 September 2017

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The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).

27 September 2017

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Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture).

27 September 2017

1 reference

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Structural analysis of Escherichia coli ThiF.

27 September 2017

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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

27 September 2017

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Nedd8 on cullin: building an expressway to protein destruction.

27 September 2017

1 reference

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Ubiquitin-like protein activation.

27 September 2017

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Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation

27 September 2017

1 reference

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Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor

27 September 2017

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Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments

27 September 2017

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The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation

27 September 2017

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Ubiquitin-like proteins: new wines in new bottles

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in vitro mutagenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

"Covalent affinity" purification of ubiquitin-activating enzyme

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Substrate properties of ubiquitin carboxyl-terminally derived peptide probes for protein ubiquitination

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Targeting SUMO E1 to Ubiquitin Ligases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Ubiquitin signalling: what's in a chain?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Distinct functional surface regions on ubiquitin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Basic Medical Research Award. The ubiquitin system

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2712597

Proteolysis: from the lysosome to ubiquitin and the proteasome

28 November 2018

1 reference

Regulated protein degradation

31 March 2020

1 reference

Ubiquitin adenylate: structure and role in ubiquitin activation

31 March 2020

1 reference

A specific inhibitor of the ubiquitin activating enzyme: synthesis and characterization of adenosyl-phospho-ubiquitinol, a nonhydrolyzable ubiquitin adenylate analogue

31 March 2020

1 reference

A viable ubiquitin-activating enzyme mutant for evaluating ubiquitin system function in Saccharomyces cerevisiae

31 March 2020

1 reference

Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme

31 March 2020

1 reference

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

31 March 2020

1 reference

Functional heterogeneity of ubiquitin carrier proteins

31 March 2020

1 reference

12 December 2020

Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation

1 reference

12 December 2020

The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes

1 reference

12 December 2020

Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation

1 reference

12 December 2020

Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1)

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM2673

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 January 2020

1049500597

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19352404%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

19352404

2 references