Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2 (Q24655602)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357310%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2 (English)

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25 January 2020

1

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25 January 2020

Munehito Arai

3

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25 January 2020

H. Jane Dyson

5

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25 January 2020

Peter Wright

6

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25 January 2020

author name string

Chul Won Lee

2

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25 January 2020

Maria A Martinez-Yamout

4

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25 January 2020

language of work or name

English

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publication date

8 April 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357310%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

25 January 2020

published in

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25 January 2020

volume

106

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25 January 2020

issue

16

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25 January 2020

page(s)

6591-6596

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Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage

25 January 2020

cites work

1 reference

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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

7 April 2017

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MDM2 suppresses p73 function without promoting p73 degradation

7 April 2017

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Binding and modulation of p53 by p300/CBP coactivators

7 April 2017

1 reference

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Synergistic activation of transcription by CBP and p53

7 April 2017

1 reference

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 April 2017

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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

7 April 2017

1 reference

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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators

7 April 2017

1 reference

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Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

7 April 2017

1 reference

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Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

7 April 2017

2 references

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7 April 2017

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

22 April 2017

1 reference

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p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

7 April 2017

1 reference

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Recruitment of p300/CBP in p53-dependent signal pathways

7 April 2017

1 reference

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

7 April 2017

1 reference

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p53 ubiquitination: Mdm2 and beyond

7 April 2017

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

7 April 2017

1 reference

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Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis

7 April 2017

1 reference

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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Structural details on mdm2-p53 interaction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

28 September 2017

1 reference

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Post-translational modification of p53 in tumorigenesis

28 September 2017

1 reference

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The N-terminal domain of p53 is natively unfolded.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Regulation of p53 responses by post-translational modifications

28 September 2017

1 reference

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Molecular mechanism of the interaction between MDM2 and p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

28 September 2017

1 reference

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Definition of the p53 functional domains necessary for inducing apoptosis

28 September 2017

1 reference

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

28 September 2017

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

28 September 2017

1 reference

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Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

28 September 2017

1 reference

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The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2.

30 May 2018

1 reference

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A novel two-site binding equation presented in terms of the total ligand concentration.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672497

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811023106

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811023106

p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811023106

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811023106

Latent and active p53 are identical in conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0811023106

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

21 January 2018

1 reference

12 December 2020

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

12 December 2020

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

12 December 2020

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0811023106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357310%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

ADS bibcode

2009PNAS..106.6591F

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357310%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

19357310

2 references