A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts (Q24658122)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071039

ncRNA catabolic process

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0034661

nuclear polyadenylation-dependent rRNA catabolic process

1 reference

Gene Ontology release 2020-05-02

1 reference

TRAMP complex RNA-binding subunit YDL175C

1 reference

Non-canonical poly(A) polymerase PAP2 YOL115W

1 reference

Exosome non-catalytic core subunit SKI6 YGR195W

1 reference

TRAMP complex RNA-binding subunit YIL079C

1 reference

Exosome non-catalytic core subunit MTR3 YGR158C

1 reference

Lrp1p YHR081W

1 reference

author

David Tollervey

7

0 references

Juri Rappsilber

4

0 references

Laura Milligan

Laura Milligan

1

0 references

Hugo Ceulemans

Hugo Ceulemans

5

0 references

Cosmin Saveanu

Cosmin Saveanu

3

0 references

Alain Jacquier

Alain Jacquier

6

0 references

author name string

Laurence Decourty

Molecular and Cellular Biology

2

0 references

language of work or name

English

0 references

publication date

September 2008

0 references

published in

0 references

volume

28

0 references

issue

17

0 references

page(s)

5446-57

0 references

cites work

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MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation

7 April 2017

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A new yeast poly(A) polymerase complex involved in RNA quality control

7 April 2017

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Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast

7 April 2017

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Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA

7 April 2017

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Degradation of ribosomal RNA precursors by the exosome

7 April 2017

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The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

7 April 2017

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Global analysis of protein expression in yeast

7 April 2017

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Functional profiling of the Saccharomyces cerevisiae genome

7 April 2017

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A generic protein purification method for protein complex characterization and proteome exploration

7 April 2017

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

7 April 2017

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Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control

7 April 2017

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The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein

7 April 2017

1 reference

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Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants

7 April 2017

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Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase

7 April 2017

1 reference

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Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3.

7 April 2017

1 reference

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A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

7 April 2017

1 reference

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Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae

7 April 2017

1 reference

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Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts

7 April 2017

1 reference

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Yeast Trf5p is a nuclear poly(A) polymerase

7 April 2017

1 reference

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Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A panoramic view of yeast noncoding RNA processing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation

7 April 2017

1 reference

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Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p

7 April 2017

1 reference

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Ssf1p prevents premature processing of an early pre-60S ribosomal particle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Identification of a regulated pathway for nuclear pre-mRNA turnover.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Ribosome synthesis in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

RRP5 is required for formation of both 18S and 5.8S rRNA in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Mutations in nucleolar proteins lead to nucleolar accumulation of polyA+ RNA in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

The nuclear RNA surveillance machinery: the link between ncRNAs and genome structure in budding yeast?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

RNA-quality control by the exosome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3' processing pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Transcriptional noise and the fidelity of initiation by RNA polymerase II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A link between transcription and mRNP quality in Saccharomyces cerevisiae.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

A dominant negative mutation in the conserved RNA helicase motif 'SAT' causes splicing factor PRP2 to stall in spliceosomes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519741

Microcolumns with self-assembled particle frits for proteomics

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18591258

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18591258

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18591258