Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand (Q24676976)

1

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Xiang Li

2

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Mark H Pausch

3

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Bryan L Roth

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

20 March 2007

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published in

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volume

104

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issue

12

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page(s)

5163-8

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cites work

Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin

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Controlling signaling with a specifically designed Gi-coupled receptor

7 April 2017

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Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor

7 April 2017

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Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D

7 April 2017

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Allele-specific activation of genetically engineered receptors

7 April 2017

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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

7 April 2017

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Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants

7 April 2017

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

7 April 2017

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New concepts in drug discovery: collateral efficacy and permissive antagonism

7 April 2017

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28 September 2017

Mining the receptorome

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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

28 September 2017

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Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

28 September 2017

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The receptors for mammalian sweet and umami taste

28 September 2017

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

28 September 2017

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N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo

28 September 2017

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Unnatural ligands for engineered proteins: new tools for chemical genetics

28 September 2017

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Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor

28 September 2017

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A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

28 September 2017

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A simple and highly efficient procedure for rescuing autonomous plasmids from yeast

28 September 2017

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Disparate ligand-mediated Ca(2+) responses by wild-type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites

28 September 2017

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The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis.

30 May 2018

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Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice

30 May 2018

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Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor

30 May 2018

1 reference

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A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).

28 November 2018

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Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons

28 November 2018

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A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

28 November 2018

1 reference

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Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.

28 November 2018

1 reference

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Engineering receptors activated solely by synthetic ligands (RASSLs).

28 November 2018

1 reference

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

28 November 2018

1 reference

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Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1829280

Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17360345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17360345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0700293104

1 reference

ADS bibcode

2007PNAS..104.5163A

0 references

1 reference

1 reference

PubMed publication ID

17360345

1 reference