Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor (Q24681280)

Molecular and Cellular Endocrinology

Europe PubMed Central

title

Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor (English)

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author name string

Ana Claudia Latronico

series ordinal

1

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Deborah L Segaloff

series ordinal

2

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language of work or name

English

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publication date

2 January 2007

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published in

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volume

260-262

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page(s)

287-93

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cites work

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Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7

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The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor

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12 December 2020

The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes

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Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor

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Treatment of familial male precocious puberty with spironolactone, testolactone, and deslorelin

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Response to challenge with gonadotropin-releasing hormone agonist in a mother and her two sons with a constitutively activating mutation of the luteinizing hormone receptor--a clinical research center study

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Long-term outcome of male-limited gonadotropin-independent precocious puberty

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