BRCA1, a 'complex' protein involved in the maintenance of genomic stability (Q26853262)

D. Paul Harkin

series ordinal

2

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language of work or name

1 reference

February 2015

1 reference

1 reference

282

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PubMed

issue

4

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PubMed

page(s)

630-46

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

PubMed

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Identification of the breast cancer susceptibility gene BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Inherited susceptibility to common cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The ubiquitin E3 ligase activity of BRCA1 and its biological functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Identification of a functional nuclear export sequence in BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 accelerates CtIP-mediated DNA-end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

53BP1: pro choice in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Luring BRCA1 to the scene of the crime

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Nucleotide excision repair in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 regulates the interferon gamma-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

NF-κB is a critical mediator of BRCA1-induced chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Estrogen receptors: how do they signal and what are their targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 interacts with components of the histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Functional selectivity of recombinant mammalian SWI/SNF subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Transcriptional regulation of the base excision repair pathway by BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Redistribution of BRCA1 among four different protein complexes following replication blockage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Luteinising hormone releasing hormone agonists (LH-RHa) in premenopausal early breast cancer patients: current role and future perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Endocrine effects of adjuvant letrozole + triptorelin compared with tamoxifen + triptorelin in premenopausal patients with early breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Transcriptional activation by BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13150

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1111/FEBS.13150

1 reference

Consolidated OpenCitations Corpus – April 2017

release_d2ncxrsx2fbdlmoic7cemfzspm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d2ncxrsx2fbdlmoic7cemfzspm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25400280

1 reference

Consolidated OpenCitations Corpus – April 2017