Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity (Q27008200)

International Journal of Molecular Sciences

language of work or name

1 reference

15 October 2014

5 references

30 June 2019

20 November 2019

27 October 2020

24 June 2021

5 references

30 June 2019

20 November 2019

27 October 2020

24 June 2021

15

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issue

10

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page(s)

18574-92

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Creative Commons Attribution

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4 references

30 June 2019

20 November 2019

27 October 2020

24 June 2021

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cites work

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

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IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

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Bcl6 mediates the development of T follicular helper cells

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A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

21 March 2017

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

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21 March 2017

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

7 April 2017

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Exogenous IL-2 controls the balance in Th1, Th17, and Treg cell distribution in patients with progressive rheumatoid arthritis treated with TNF-alpha inhibitors

7 April 2017

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Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy

28 September 2017

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Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance

28 September 2017

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Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients

28 September 2017

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Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

28 September 2017

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β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice

28 September 2017

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Intersection between genetic polymorphisms and immune deviation in type 1 diabetes

28 September 2017

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Role of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function

28 September 2017

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Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes

28 September 2017

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Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

28 September 2017

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Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

28 September 2017

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Th17 cells in type 1 diabetes

28 September 2017

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Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

28 September 2017

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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

28 September 2017

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STAT5 is a potent negative regulator of TFH cell differentiation

28 September 2017

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Interleukin-2 and regulatory T cells in graft-versus-host disease

28 September 2017

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Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

28 September 2017

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CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game

28 September 2017

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Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells

28 September 2017

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gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma

28 September 2017

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Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227233

Type 1 diabetes: etiology, immunology, and therapeutic strategies

28 September 2017

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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

28 September 2017

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Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

28 September 2017

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IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

28 September 2017

1 reference

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

28 September 2017

1 reference

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Interleukin-2 therapy in patients with HIV infection

28 September 2017

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

28 September 2017

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Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation

28 September 2017

1 reference

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Control of regulatory T cell lineage commitment and maintenance

28 September 2017

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Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

28 September 2017

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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

28 September 2017

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Follicular helper T cells are required for systemic autoimmunity

28 September 2017

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Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice

28 September 2017

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28 September 2017

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The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice

28 September 2017

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Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells

28 September 2017

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STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

28 September 2017

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IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.

28 September 2017

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Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

28 September 2017

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Cytokines and T-cell homeostasis

28 September 2017

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

28 September 2017

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

28 September 2017

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

28 September 2017

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CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis.

28 September 2017

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The NOD mouse model of type 1 diabetes: as good as it gets?

28 September 2017

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Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease

28 September 2017

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

28 September 2017

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Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2

28 September 2017

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Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer

28 September 2017

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Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

28 September 2017

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Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer

31 May 2018

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Cytokines and Regulatory T Cells in Rheumatoid Arthritis and Their Relationship with Response to Corticosteroids

31 May 2018

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The initial phase of an immune response functions to activate regulatory T cells

31 May 2018

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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

31 May 2018

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Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

21 January 2018

1 reference

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IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Peripheral blood Th17/Treg imbalance in patients with low-active systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Beta cell function during rapamycin monotherapy in long-term type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

A glucocorticoid amplifies IL-2-induced selective expansion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Interleukin 10 and tumor necrosis factor-alpha genotypes in rheumatoid arthritis--association with clinical response to glucocorticoids

21 January 2018

1 reference

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Phase I trial of BAY 50-4798, an interleukin-2-specific agonist in advanced melanoma and renal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS151018574

Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem cell factor plus granulocyte colony-stimulating factor.

21 January 2018

1 reference

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Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis

28 November 2018

1 reference

12 December 2020

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice

1 reference

12 December 2020

Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE

1 reference

12 December 2020

IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice

1 reference

12 December 2020

Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15

1 reference

12 December 2020

mRNA quantification of T-bet, GATA-3, IFN-gamma, and IL-4 shows a defective Th1 immune response in the peripheral blood from rheumatoid arthritis patients: link with disease activity

1 reference

12 December 2020

Restoration of an early, progressive defect in responsiveness to T-cell activation in lupus mice by exogenous IL-2

1 reference

12 December 2020

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

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12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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12 December 2020

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS151018574

1 reference

1 reference

1 reference

PubMed publication ID

25322151

1 reference