Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions (Q27014831)

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English	Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions	scientific article

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scholarly article

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Europe PubMed Central

Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions (English)

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Hepatitis C virus

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based on heuristic

inferred from title

Sreedhar Chinnaswamy

1

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Sreedhar Chinnaswamy

1

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language of work or name

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publication date

July 2014

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number of pages

19

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Journal of Interferon and Cytokine Research

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

34

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

7

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

479-497

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Emerging therapies for the treatment of hepatitis C

1 reference

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21 March 2017

Regulation of hepatic innate immunity by hepatitis C virus

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21 March 2017

Chapter 11: Genome-wide association studies

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21 March 2017

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

1 reference

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21 March 2017

Induction and function of type I and III interferon in response to viral infection

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21 March 2017

Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus

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21 March 2017

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

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21 March 2017

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

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21 March 2017

IL-28, IL-29 and their class II cytokine receptor IL-28R

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21 March 2017

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication

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21 March 2017

Interferon- Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

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21 March 2017

Expert opinion on the treatment of patients with chronic hepatitis C

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21 March 2017

Interferon signaling and treatment outcome in chronic hepatitis C

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21 March 2017

STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?

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21 March 2017

Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA

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21 March 2017

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

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21 March 2017

Hepatitis C virus infection

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21 March 2017

Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus

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21 March 2017

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

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21 March 2017

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

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21 March 2017

Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses

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21 March 2017

IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes

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21 March 2017

IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study

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21 March 2017

Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

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21 March 2017

Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C

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21 March 2017

Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients

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21 March 2017

Evolving epidemiology of hepatitis C virus

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7 April 2017

IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy

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7 April 2017

Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

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7 April 2017

Common genetic variation and human traits

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7 April 2017

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs

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28 September 2017

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

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28 September 2017

A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcription

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28 September 2017

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

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28 September 2017

Host-targeting agents in the treatment of hepatitis C: a beginning and an end?

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28 September 2017

Distilling pathophysiology from complex disease genetics

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28 September 2017

Different effects of three interferons L on Toll-like receptor-related gene expression in HepG2 cells

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28 September 2017

Is 3 the new 1: perspectives on virology, natural history and treatment for hepatitis C genotype 3.

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28 September 2017

Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

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28 September 2017

Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection

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28 September 2017

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

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28 September 2017

Ex vivo induction of IFN-λ3 by a TLR7 agonist determines response to Peg-IFN/ribavirin therapy in chronic hepatitis C patients

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28 September 2017

IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication

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Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-β2 expression via DNA methylation

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Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication

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28 September 2017

Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus

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28 September 2017

Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms?

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28 September 2017

Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells.

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28 September 2017

Hepatitis C virus infection suppresses GLUT2 gene expression via downregulation of hepatocyte nuclear factor 1α.

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28 September 2017

Does IL28B genotyping still have a role in the era of direct-acting antiviral therapy for chronic hepatitis C infection?

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28 September 2017

Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells

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28 September 2017

Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus

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28 September 2017

IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection

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28 September 2017

IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population

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28 September 2017

Genetics of IL28B and HCV--response to infection and treatment

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28 September 2017

The pharmacogenetic background of hepatitis C treatment

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28 September 2017

Protease inhibitors: silver bullets for chronic hepatitis C infection?

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28 September 2017

Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response

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28 September 2017

Deciphering the interleukin 28B variants that better predict response to pegylated interferon-α and ribavirin therapy in HCV/HIV-1 coinfected patients

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28 September 2017

Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV

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28 September 2017

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28 September 2017

Genetic variation of the IL-28B promoter affecting gene expression

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28 September 2017

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28 September 2017

Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance

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28 September 2017

IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

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28 September 2017

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28 September 2017

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.

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28 September 2017

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus

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28 September 2017

Progress and promise of genome-wide association studies for human complex trait genetics

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28 September 2017

IL28B and the Control of Hepatitis C Virus Infection

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28 September 2017

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.

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28 September 2017

Host genetic basis for hepatitis C virus clearance: a role for blood collection centers

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28 September 2017

The structure of human interferon lambda and what it has taught us.

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28 September 2017

Interferon-lambda: a new addition to an old family

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28 September 2017

Uncovering the roles of rare variants in common disease through whole-genome sequencing

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28 September 2017

Induction and evasion of innate antiviral responses by hepatitis C virus

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Intracellular innate immune cascades and interferon defenses that control hepatitis C virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Human interferon-lambda3 is a potent member of the type III interferon family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Hemophilic siblings with chronic hepatitis C: Familial aggregation of spontaneous and treatment-related viral clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Viral factors affecting the outcome of therapy for chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Hepatitis C in African Americans: summary of a workshop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Genetics of complex disease: approaches, problems, and solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 September 2017

Lambda interferon serum levels in patients with chronic hepatitis C virus infection according to their response to therapy with pegylated interferon and ribavirin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

31 May 2018

IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

31 May 2018

Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

31 May 2018

Variations at multiple genes improve interleukin 28B genotype predictive capacity for response to therapy against hepatitis C infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

31 May 2018

IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

31 May 2018

'Favourable' IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Meta-analysis: the impact of IL28B polymorphisms on rapid and sustained virological response in HCV-2 and -3 patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Hepatitis C virus NS3/4A protease blocks IL-28 production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Insights into the role of interferon lambda in hepatitis C virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Interferon-lambda serum levels in hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080901

28 November 2018

In the Absence of HCV Infection, Interferon Stimulated Gene Expression in Liver Is Not Associated With IL28B Genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL28B genotype and the expression of ISGs in normal liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/JIR.2013.0113

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

release_hejewysdsnd47edjnby47d5mqe

0 references

PMC publication ID

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24555572%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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