E2 ubiquitin-conjugating protein RAD6 YGL058W (Q27547682)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06104

Ubiquitin-conjugating enzyme E2 family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

ubiquitin protein ligase binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

IBA

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

single-stranded DNA helicase activity

1 reference

27 March 2018

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

ubiquitin protein ligase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

single-stranded DNA binding

IBA

1 reference

27 March 2018

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

protein binding

10 references

27 March 2018

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Defining the budding yeast chromatin-associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

cell component

Rad6-Rad18 complex

1 reference

27 March 2018

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

HULC complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

IBA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

3 references

27 March 2018

27 March 2018

The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

proteasome complex

1 reference

27 March 2018

Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

MUB1-RAD6-UBR2 ubiquitin ligase complex

1 reference

27 March 2018

Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

telomere

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

UBR1-RAD6 ubiquitin ligase complex

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

N-recognin/Ubc2 interactions in the N-end rule pathway.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

N-recognin/Ubc2 interactions in the N-end rule pathway.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

telomere maintenance via recombination

biological process

1 reference

27 March 2018

Telomerase-null survivor screening identifies novel telomere recombination regulators.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

ubiquitin-dependent ERAD pathway

1 reference

27 March 2018

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

transcription by RNA polymerase II

1 reference

27 March 2018

Histone H2B ubiquitylation is associated with elongating RNA polymerase II

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

regulation of dipeptide transport

1 reference

27 March 2018

The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

error-prone translesion synthesis

1 reference

27 March 2018

UV mutagenesis in radiation-sensitive strains of yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

protein K63-linked ubiquitination

1 reference

27 March 2018

K63 polyubiquitination is a new modulator of the oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

cytoplasm protein quality control by the ubiquitin-proteasome system

1 reference

27 March 2018

Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

DNA-templated transcription, termination

1 reference

27 March 2018

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

meiotic DNA double-strand break formation

1 reference

27 March 2018

Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

protein monoubiquitination

1 reference

27 March 2018

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

sporulation resulting in formation of a cellular spore

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

double-strand break repair via homologous recombination

1 reference

27 March 2018

The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

error-free translesion synthesis

1 reference

27 March 2018

The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

mitotic G1 DNA damage checkpoint signaling

error-free postreplication DNA repair

1 reference

27 March 2018

MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

1 reference

27 March 2018

ubiquitin-dependent protein catabolic process

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

27 March 2018

The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06104&geneProductId=UniProtKB:P06104

Ubiquitin-conjugating enzyme, active site

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06104

Ubiquitin-conjugating enzyme E2

1 reference

InterPro Release 71.0