Mismatch repair ATPase MSH2 YOL090W (Q27550737)

DNA mismatch repair protein MutS, N-terminal domain, protein family

1 reference

DNA mismatch repair protein MutS, core domain superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

MutS, connector domain superfamily

1 reference

DNA mismatch repair protein MutS, connector domain, protein family

1 reference

DNA mismatch repair protein MutS, C-terminal domain, protein family

1 reference

DNA mismatch repair protein MutS, clamp, protein family

1 reference

DNA mismatch repair protein MutS, core domain, protein family

1 reference

DNA mismatch repair protein MutS-like, N-terminal domain, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

27 March 2018

27 March 2018

ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

double-strand/single-strand DNA junction binding

1 reference

14 February 2019

Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

four-way junction DNA binding

2 references

27 March 2018

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

27 March 2018

'Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

guanine/thymine mispair binding

1 reference

27 March 2018

The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

mismatched DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

1 reference

9 May 2019

heteroduplex DNA loop binding

1 reference

9 May 2019

Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

Y-form DNA binding

1 reference

9 May 2019

Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

ATPase activity

1 reference

9 May 2019

Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

single base insertion or deletion binding

Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

DNA insertion or deletion binding

1 reference

9 May 2019

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

protein binding

7 references

9 May 2019

Conserved properties between functionally distinct MutS homologs in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Proteome-wide protein interaction measurements of bacterial proteins of unknown function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

ATP-dependent activity, acting on DNA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

damaged DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

magnesium ion binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

four-way junction DNA binding

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

'Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

Y-form DNA binding

heteroduplex DNA loop binding

double-strand/single-strand DNA junction binding

single-stranded DNA binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

9 May 2019

ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

protein kinase binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

guanine/thymine mispair binding

single guanine insertion binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

single thymine insertion binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

dinucleotide repeat insertion binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

oxidized purine DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

MutLalpha complex binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

protein homodimerization activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

ADP binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

cell component

mismatch repair complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

1 reference

27 March 2018

MutSalpha complex

1 reference

27 March 2018

The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

MutSbeta complex

1 reference

27 March 2018

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

nuclear chromosome

1 reference

9 May 2019

The Saccharomyces cerevisiae Msh2 mismatch repair protein localizes to recombination intermediates in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

1 reference

10 September 2018

nuclear chromosome

MutSalpha complex

MutSbeta complex

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

3 references

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Global analysis of protein localization in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

silent mating-type cassette heterochromatin assembly

HDA

biological process

1 reference

9 May 2019

Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

replication fork arrest

1 reference

9 May 2019

Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

meiotic gene conversion

1 reference

9 May 2019

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

interstrand cross-link repair

1 reference

9 May 2019

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

mitotic recombination

1 reference

9 May 2019

Requirement of mismatch repair genes MSH2 and MSH3 in the RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

1 reference

9 May 2019

meiotic mismatch repair

3 references

9 May 2019

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

DNA mismatch repair

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

27 March 2018

Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

27 March 2018

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

1 reference

9 May 2019

DNA recombination

1 reference

14 February 2019

Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

removal of nonhomologous ends

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

postreplication repair

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

maintenance of DNA repeat elements

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

negative regulation of reciprocal meiotic recombination

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

meiotic mismatch repair

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

10 September 2018

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

10 September 2018

Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

pyrimidine dimer repair

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

DNA mismatch repair

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

meiotic gene conversion

2 references

mitotic recombination

interstrand cross-link repair

replication fork arrest

positive regulation of helicase activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25847&geneProductId=UniProtKB:P25847

negative regulation of DNA recombination

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25847

DNA recombination

DNA mismatch repair protein MutS, C-terminal

has part(s)

1 reference

DNA mismatch repair protein MutS-like, N-terminal

1 reference

DNA mismatch repair protein MutS, core

1 reference

DNA mismatch repair protein MutS, clamp

1 reference

DNA mismatch repair protein MutS, connector domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference