E3 ubiquitin-protein ligase HRD1 YOL013C (Q27551164)

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fungal protein found in Saccharomyces cerevisiae S288c
  • YOL013C
  • E3 ubiquitin-protein ligase HRD1
  • HRD1
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Language Label Description Also known as
English
E3 ubiquitin-protein ligase HRD1 YOL013C
fungal protein found in Saccharomyces cerevisiae S288c
  • YOL013C
  • E3 ubiquitin-protein ligase HRD1
  • HRD1

Statements

molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
14 February 2019
stated in
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Ubx2 links the Cdc48 complex to ER-associated protein degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Sec61p is part of the endoplasmic reticulum-associated degradation machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Key steps in ERAD of luminal ER proteins reconstituted with purified components
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Proteome survey reveals modularity of the yeast cell machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
cell component
biological process
ubiquitin-dependent ERAD pathway
determination method or standard
IDA
IEA
IMP
IPI
6 references
retrieved
14 February 2019
stated in
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
GOA
curator
SGD
Saccharomyces Genome Database ID
S000005373
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IPI
retrieved
14 February 2019
stated in
Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase
GOA
curator
SGD
Saccharomyces Genome Database ID
S000005373
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IMP
retrieved
14 February 2019
stated in
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
GOA
curator
SGD
Saccharomyces Genome Database ID
S000005373
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IMP
retrieved
14 February 2019
stated in
Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation
GOA
curator
SGD
Saccharomyces Genome Database ID
S000005373
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IEA
retrieved
14 February 2019
stated in
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08109
determination method or standard
IDA

Identifiers

 
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