Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport (Q27617536)

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C Nowak

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T Nishimoto

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J Kuhlmann

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A Wittinghofer

Transport into and out of the cell nucleus

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language of work or name

English

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publication date

4 March 1999

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published in

Nature

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volume

398

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issue

6722

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page(s)

39-46

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cites work

1 reference

A family of Ran binding proteins that includes nucleoporins

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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CRM1 is an export receptor for leucine-rich nuclear export signals

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The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein

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RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex

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A giant nucleopore protein that binds Ran/TC4

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Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region

21 January 2018

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The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

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GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import

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Two-way trafficking with Ran.

21 January 2018

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Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

21 January 2018

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Structure of the human ADP-ribosylation factor 1 complexed with GDP

21 January 2018

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The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

21 January 2018

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An alpha to beta conformational switch in EF-Tu

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Helix unwinding in the effector region of elongation factor EF-Tu-GDP

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The structure of Ras protein: a model for a universal molecular switch

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Structural Basis for Activation of ARF GTPase

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NTF2 mediates nuclear import of Ran.

21 January 2018

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Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran

21 January 2018

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The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif

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Pleckstrin homology domains: a fact file

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Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

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Analytical molecular surface calculation

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Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

21 January 2018

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

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RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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The CCP4 suite: programs for protein crystallography

21 January 2018

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

21 January 2018

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D Version 2.0. A program for photorealistic molecular graphics

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

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RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

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Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

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7 January 2021

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

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7 January 2021

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

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7 January 2021

Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1

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7 January 2021

Structure of the binding site for inositol phosphates in a PH domain

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7 January 2021

Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization

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7 January 2021

Electron-density map interpretation

1 reference

7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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7 January 2021