Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue (Q27629942)

2

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D Belorgey

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M Braun

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R Kiefersauer

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K Maskos

6

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R Huber

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H Rubin

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W Bode

Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9

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publication date

December 2000

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published in

Biological Chemistry

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volume

381

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issue

12

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page(s)

1203-14

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cites work

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The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

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Conversion of the substrate specificity of mouse proteinase granzyme B

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Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9.

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold

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Accurate bond and angle parameters for X-ray protein structure refinement

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

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Definition and redesign of the extended substrate specificity of granzyme B.

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

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Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

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A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes

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Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes

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PROCHECK: a program to check the stereochemical quality of protein structures

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A

21 January 2018

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

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Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

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Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

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Structure of human des(1-45) factor Xa at 2.2 A resolution

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The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

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Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays

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Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

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Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

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Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases

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Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

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Caspases - controlling intracellular signals by protease zymogen activation

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Expression and purification of recombinant human granzyme B from Pichia pastoris

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

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Cytotoxic T cells: more weapons for new targets?

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Recombinant expression of human mast cell proteases chymase and tryptase

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

21 January 2018

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The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

21 January 2018

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Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system

21 January 2018

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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

21 January 2018

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Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

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Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity

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