The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain (Q27646344)

1

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Sung Hee Choi

2

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Diego Alvarado

3

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Katarina Moravcevic

4

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Ambra Pozzi

5

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Graham Carpenter

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

7

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publication date

26 June 2009

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published in

Molecular Cell

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volume

34

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issue

6

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page(s)

641-51

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cites work

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'Classical' but not 'other' mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer

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The HER family and cancer: emerging molecular mechanisms and therapeutic targets

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29 September 2017

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29 September 2017

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29 September 2017

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EGF receptor residues leu(679), leu(680) mediate selective sorting of ligand-receptor complexes in early endosomal compartments

29 September 2017

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A leucine-based determinant in the epidermal growth factor receptor juxtamembrane domain is required for the efficient transport of ligand-receptor complexes to lysosomes

29 September 2017

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Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

29 September 2017

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Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor

29 September 2017

1 reference

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A negative feedback loop attenuates EGF-induced morphological changes

29 September 2017

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Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase

29 September 2017

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The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site.

29 September 2017

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Characterization of a novel tripartite nuclear localization sequence in the EGFR family

2 June 2018

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Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719887

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719887

A basic peptide within the juxtamembrane region is required for EGF receptor dimerization

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719887

Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome

27 November 2018

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12 December 2020

Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells

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12 December 2020

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

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12 December 2020

Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression

1 reference

12 December 2020

10.1016/J.MOLCEL.2009.04.034

Identifiers

DOI

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PubMed publication ID

19560417

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