A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation (Q27649579)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209102%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation (English)

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1 January 2020

0 references

0 references

1

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1 January 2020

Mark F van Delft

3

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1 January 2020

Ewa Michalak

4

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1 January 2020

Michelle J Boyle

5

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1 January 2020

Hamsa Puthalakath

7

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1 January 2020

Philippe Bouillet

8

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1 January 2020

David C Huang

10

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1 January 2020

Walter D Fairlie

11

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1 January 2020

2

Peter E Czabotar

1 reference

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1 January 2020

6

Simon N Willis

1 reference

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1 January 2020

author name string

Peter M Colman

9

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1 January 2020

language of work or name

English

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publication date

21 January 2008

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1 January 2020

number of pages

15

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inferred from page(s)

published in

Journal of Cell Biology

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1 January 2020

volume

180

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1 January 2020

issue

2

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1 January 2020

page(s)

341-355

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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

1 January 2020

cites work

1 reference

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

20 March 2017

1 reference

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A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

20 March 2017

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

20 March 2017

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

20 March 2017

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

20 March 2017

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

20 March 2017

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

20 March 2017

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Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

20 March 2017

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

20 March 2017

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

20 March 2017

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

20 March 2017

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

20 March 2017

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Likelihood-enhanced fast rotation functions

20 March 2017

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Pushing the boundaries of molecular replacement with maximum likelihood

20 March 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

20 March 2017

1 reference

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

20 March 2017

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Processing of X-ray diffraction data collected in oscillation mode

20 March 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

22 April 2017

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ER stress triggers apoptosis by activating BH3-only protein Bim

7 April 2017

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

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Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

7 April 2017

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

29 September 2017

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

29 September 2017

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Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

29 September 2017

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Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

29 September 2017

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Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy

29 September 2017

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Life in the balance: how BH3-only proteins induce apoptosis.

29 September 2017

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Promoting apoptosis as a strategy for cancer drug discovery

29 September 2017

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Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

29 September 2017

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

29 September 2017

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Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.

29 September 2017

1 reference

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Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

29 September 2017

1 reference

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Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells.

29 September 2017

1 reference

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

29 September 2017

1 reference

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The Bcl-2 family: roles in cell survival and oncogenesis.

29 September 2017

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

29 September 2017

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A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

29 September 2017

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

29 September 2017

1 reference

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MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

29 September 2017

1 reference

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

29 September 2017

1 reference

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Phage display for selection of novel binding peptides

29 September 2017

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Mcl-1 deficiency results in peri-implantation embryonic lethality

29 September 2017

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Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes

29 September 2017

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

29 September 2017

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The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

29 September 2017

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Efficient site-directed mutagenesis using uracil-containing DNA.

29 September 2017

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

29 September 2017

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

2 June 2018

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

2 June 2018

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Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected].

2 June 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

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Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia

21 January 2018

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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.

21 January 2018

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Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

27 November 2018

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Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

27 November 2018

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Unraveling MCL-1 degradation

27 November 2018

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12 December 2020

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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12 December 2020

The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1

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12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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12 December 2020

Identifiers

DOI

10.1083/JCB.200708096

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209102%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209102%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

18209102

2 references