Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases (Q27652488)

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15 January 2020

title

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases (English)

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15 January 2020

0 references

1 reference

ChEBI release 2020-05-28

3

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15 January 2020

Tamim M Nazif

4

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15 January 2020

Roger L. Williams

8

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15 January 2020

Zachary A Knight

10

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15 January 2020

author name string

Beth Apsel

1

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15 January 2020

Jimmy A Blair

2

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15 January 2020

Morri E Feldman

5

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15 January 2020

Brian Aizenstein

6

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15 January 2020

Randy Hoffman

7

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15 January 2020

Kevan M Shokat

9

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15 January 2020

publication date

12 October 2008

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15 January 2020

published in

Nature Chemical Biology

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15 January 2020

volume

4

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15 January 2020

issue

11

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15 January 2020

page(s)

691-699

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Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

15 January 2020

cites work

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

20 March 2017

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

20 March 2017

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20 March 2017

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

20 March 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

20 March 2017

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High frequency of mutations of the PIK3CA gene in human cancers

20 March 2017

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A quantitative analysis of kinase inhibitor selectivity

20 March 2017

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20 March 2017

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Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

20 March 2017

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

20 March 2017

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

20 March 2017

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

7 April 2017

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Rational design of inhibitors that bind to inactive kinase conformations

7 April 2017

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

7 April 2017

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

7 April 2017

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 April 2017

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

7 April 2017

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7 April 2017

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

29 September 2017

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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells

29 September 2017

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29 September 2017

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

29 September 2017

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BAY 43-9006 inhibition of oncogenic RET mutants

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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Chemically targeting the PI3K family

27 November 2018

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Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

27 November 2018

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Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

27 November 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

27 November 2018

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

27 November 2018

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Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

27 November 2018

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A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

27 November 2018

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12 December 2020

Structural basis for selective inhibition of Src family kinases by PP1

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12 December 2020

Oncogenic mutations of PIK3CA in human cancers

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12 December 2020

Tyrosine kinases as targets for cancer therapy

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12 December 2020

Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.117

2 references

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Dimensions Publication ID

15 January 2020

1016767348

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Fatcat ID

release_eemn74fmyvddtdeiywfjz2mtui

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Fatcat

https://api.fatcat.wiki/v0/release/eemn74fmyvddtdeiywfjz2mtui

24 November 2022

mapped directly with Wikidata item

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2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18849971%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

18849971

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