Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans (Q27675205)

2

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Emi Takemoto

3

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Mami Shibata-Koyama

4

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Yuya Isoda

5

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Shigeru Iida

6

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Kazuhiro Masuda

7

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Mitsuo Satoh

8

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Koichi Kato

Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1

9

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publication date

November 2011

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published in

Genes to Cells

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volume

16

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issue

11

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page(s)

1071-80

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cites work

1 reference

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The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

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Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

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The interpretation of protein structures: Estimation of static accessibility

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Production of therapeutic antibodies with controlled fucosylation

20 March 2017

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Engineered therapeutic antibodies with improved effector functions

29 September 2017

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Glycosylation as a strategy to improve antibody-based therapeutics

29 September 2017

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The N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylation

29 September 2017

1 reference

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Decoding sugar functions by identifying target glycoproteins

29 September 2017

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Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy.

29 September 2017

1 reference

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The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms

29 September 2017

1 reference

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Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIa

29 September 2017

1 reference

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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

29 September 2017

1 reference

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N-glycosylation profile of recombinant human soluble Fcgamma receptor III.

29 September 2017

1 reference

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

29 September 2017

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The role of glycosylation in ionotropic glutamate receptor ligand binding, function, and trafficking

29 September 2017

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

29 September 2017

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IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation

29 September 2017

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Human antibody effector function

29 September 2017

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Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions.

29 September 2017

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Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

2 June 2018

1 reference

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The therapeutic antibodies market to 2008.

27 November 2018

1 reference

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Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258418

Monoclonal antibody successes in the clinic

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22023369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22023369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1365-2443.2011.01552.X

1 reference

1 reference

1 reference

PubMed publication ID

22023369

1 reference