Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub (Q27678519)

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2 March 2020

title

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub (English)

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2 March 2020

2

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2 March 2020

Susan van Erp

3

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2 March 2020

Robert J Gilbert

6

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2 March 2020

Jeroen Pasterkamp

8

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2 March 2020

author name string

Christian H Bell

1

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2 March 2020

Benjamin Bishop

4

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2 March 2020

Chenxiang Tang

5

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2 March 2020

A Radu Aricescu

7

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2 March 2020

Christian Siebold

9

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2 March 2020

language of work or name

English

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publication date

6 June 2013

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2 March 2020

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2 March 2020

volume

341

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2 March 2020

issue

6141

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2 March 2020

page(s)

77-80

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Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å

2 March 2020

cites work

1 reference

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Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains

20 March 2017

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

20 March 2017

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

20 March 2017

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

20 March 2017

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Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

20 March 2017

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RGM is a repulsive guidance molecule for retinal axons

20 March 2017

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Neogenin mediates the action of repulsive guidance molecule

20 March 2017

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Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

20 March 2017

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Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system

20 March 2017

1 reference

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RGMa inhibition promotes axonal growth and recovery after spinal cord injury.

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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22 April 2017

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Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

22 April 2017

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22 April 2017

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22 April 2017

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22 April 2017

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22 April 2017

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Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

22 April 2017

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Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain

22 April 2017

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Biochemistry and genetics of von Willebrand factor

22 April 2017

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PHENIX: building new software for automated crystallographic structure determination

22 April 2017

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A time- and cost-efficient system for high-level protein production in mammalian cells

22 April 2017

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A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

22 April 2017

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Netrins: versatile extracellular cues with diverse functions

22 April 2017

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Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation

29 September 2017

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Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages

29 September 2017

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Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation

29 September 2017

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Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms

29 September 2017

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Unc5B associates with LARG to mediate the action of repulsive guidance molecule

29 September 2017

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Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

29 September 2017

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Neogenin: one receptor, many functions

29 September 2017

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Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

29 September 2017

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29 September 2017

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An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

29 September 2017

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Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

29 September 2017

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29 September 2017

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RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

29 September 2017

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Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin.

21 January 2018

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Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury

21 January 2018

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21 January 2018

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21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23744777

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1232322

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744777%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

0 references

1 reference

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2 March 2020

PubMed publication ID

23744777

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744777%20AND%20SRC:MED&resulttype=core&format=json