Lysophospholipid receptors in drug discovery (Q27692680)

Mizuno H

series ordinal

2

1 reference

Chun J

series ordinal

3

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language of work or name

English

0 references

publication date

1 May 2015

1 reference

Experimental Cell Research

published in

1 reference

volume

333

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issue

2

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page(s)

171-7

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Sphingosine 1-phosphate signalling

cites work

1 reference

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FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology

20 March 2017

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Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6

20 March 2017

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20 March 2017

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G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

20 March 2017

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

20 March 2017

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Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway

20 March 2017

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Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid

20 March 2017

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Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid

20 March 2017

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Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

20 March 2017

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Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids

20 March 2017

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Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex

20 March 2017

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Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

20 March 2017

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Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

20 March 2017

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LPA receptors: subtypes and biological actions

20 March 2017

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Identification of GPR55 as a lysophosphatidylinositol receptor

20 March 2017

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How many drug targets are there?

20 March 2017

1 reference

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GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5

20 March 2017

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Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes

20 March 2017

1 reference

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Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain

20 March 2017

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Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

20 March 2017

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An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors

20 March 2017

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Structural diversity of G protein-coupled receptors and significance for drug discovery

20 March 2017

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

7 April 2017

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

7 April 2017

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Novel lysophosphoplipid receptors: their structure and function

7 April 2017

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Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response

29 September 2017

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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

29 September 2017

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LPA receptor signaling: pharmacology, physiology, and pathophysiology

29 September 2017

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Lysophospholipid receptor nomenclature review: IUPHAR Review 8.

29 September 2017

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Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression

29 September 2017

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Requirement for safety monitoring for approved multiple sclerosis therapies: an overview

29 September 2017

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The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55.

29 September 2017

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Sphingosine-1-phosphate signaling and its role in disease

29 September 2017

1 reference

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Lysophosphatidic acid signaling may initiate fetal hydrocephalus.

29 September 2017

1 reference

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The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

29 September 2017

1 reference

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The outs and the ins of sphingosine-1-phosphate in immunity

29 September 2017

1 reference

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A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis

29 September 2017

1 reference

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Blood sphingolipidomics in healthy humans: impact of sample collection methodology

29 September 2017

1 reference

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A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

29 September 2017

1 reference

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Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis

29 September 2017

1 reference

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Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis

29 September 2017

1 reference

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Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

29 September 2017

1 reference

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Oral fingolimod (FTY720) for relapsing multiple sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Drug design strategies for targeting G-protein-coupled receptors

29 September 2017

1 reference

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Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

29 September 2017

1 reference

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GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Identification of a lysophosphatidylserine receptor on mast cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

Idiopathic Pulmonary Fibrosis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408218

FTY720 versus MMF with Cyclosporine in de novo Renal Transplantation: A 1-Year, Randomized Controlled Trial in Europe and Australasia

27 November 2018

1 reference

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