Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (Q27860893)

Suvendra Nath Bhattacharyya

Europe PubMed Central

title

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (English)

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series ordinal

2

object named as

Suvendra N Bhattacharyya

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Witold Filipowicz

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1

object named as

Witold Filipowicz

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publication date

February 2008

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published in

Nature Reviews Genetics

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volume

9

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issue

2

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page(s)

102-14

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The diverse functions of microRNAs in animal development and disease

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Illuminating the silence: understanding the structure and function of small RNAs

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miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

31 March 2020

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A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii

31 March 2020

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Oncomirs - microRNAs with a role in cancer

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microRNAs in vertebrate physiology and human disease

31 March 2020

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MicroRNAs: a new class of regulatory genes affecting metabolism

31 March 2020

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MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome

31 March 2020

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Control of translation and mRNA degradation by miRNAs and siRNAs

31 March 2020

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Repression of protein synthesis by miRNAs: how many mechanisms?

31 March 2020

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MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation

31 March 2020

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How do microRNAs regulate gene expression?

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Mechanisms of microRNA-mediated gene regulation in animal cells

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A hexanucleotide element directs microRNA nuclear import.

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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P bodies: at the crossroads of post-transcriptional pathways

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Function and localization of microRNAs in mammalian cells

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Assembly and function of RNA silencing complexes

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MicroRNAs: genomics, biogenesis, mechanism, and function

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microPrimer: the biogenesis and function of microRNA.

31 March 2020

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31 March 2020

Genomics of microRNA.

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Post-transcriptional gene silencing by siRNAs and miRNAs

31 March 2020

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Argonaute proteins: mediators of RNA silencing

31 March 2020

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Slicer and the argonautes

31 March 2020

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Argonaute2 is the catalytic engine of mammalian RNAi

31 March 2020

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Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

31 March 2020

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

31 March 2020

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MicroRNAS and their regulatory roles in plants

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Specificity of microRNA target selection in translational repression

31 March 2020

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Principles of microRNA-target recognition

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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MicroRNA targeting specificity in mammals: determinants beyond seed pairing

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Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

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Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR

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Substrate requirements for let-7 function in the developing zebrafish embryo

31 March 2020

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Isolation of microRNA targets by miRNP immunopurification

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Cap-dependent and cap-independent translation in eukaryotic systems

31 March 2020

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The molecular mechanics of eukaryotic translation

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Circularization of mRNA by eukaryotic translation initiation factors

31 March 2020

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Regulation of poly(A)-binding protein through PABP-interacting proteins.

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

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Relief of microRNA-mediated translational repression in human cells subjected to stress

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Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles

31 March 2020

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

31 March 2020

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A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.

31 March 2020

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An mRNA m7G cap binding-like motif within human Ago2 represses translation

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Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

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siRNAs can function as miRNAs

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Recapitulation of short RNA-directed translational gene silencing in vitro

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Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.

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MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

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Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system

31 March 2020

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MicroRNAs direct rapid deadenylation of mRNA

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MicroRNA silencing through RISC recruitment of eIF6

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The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly

31 March 2020

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The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor

31 March 2020

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The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis

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Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.

31 March 2020

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The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

31 March 2020

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

31 March 2020

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Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

31 March 2020

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Short RNAs repress translation after initiation in mammalian cells.

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Human let-7a miRNA blocks protein production on actively translating polyribosomes

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Evidence that microRNAs are associated with translating messenger RNAs in human cells

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Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

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miRNP:mRNA association in polyribosomes in a human neuronal cell line.

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AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

31 March 2020

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The STAR/Maxi-KH domain protein GLD-1 mediates a developmental switch in the translational control of C. elegans PAL-1.

31 March 2020

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Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response

31 March 2020

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Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism.

31 March 2020

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Localization-dependent oskar protein accumulation; control after the initiation of translation

31 March 2020

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Global analysis of patterns of gene expression during Drosophila embryogenesis

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

31 March 2020

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

31 March 2020

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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

31 March 2020

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Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells

31 March 2020

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Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster

31 March 2020

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Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

31 March 2020

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Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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Silencing of microRNAs in vivo with 'antagomirs'

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

31 March 2020

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Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression

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The enzymes and control of eukaryotic mRNA turnover

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P bodies and the control of mRNA translation and degradation

31 March 2020

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The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans

31 March 2020

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A role for the P-body component GW182 in microRNA function

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Disruption of GW bodies impairs mammalian RNA interference

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Identification of novel argonaute-associated proteins

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A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

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Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

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Comparison of siRNA-induced off-target RNA and protein effects

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31 March 2020

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Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies

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Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules

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Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members

31 March 2020

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P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

31 March 2020

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Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae

31 March 2020

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

31 March 2020

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Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies

31 March 2020

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Formation of GW bodies is a consequence of microRNA genesis

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General translational repression by activators of mRNA decapping

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The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer

31 March 2020

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A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

31 March 2020

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A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

31 March 2020

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RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes

31 March 2020

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

31 March 2020

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Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

31 March 2020

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GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization

31 March 2020

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Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

31 March 2020

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Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation

31 March 2020

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A brain-specific microRNA regulates dendritic spine development

31 March 2020

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Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila

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Dendritic protein synthesis, synaptic plasticity, and memory

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The neuronal microRNA system

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Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay

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Intronic microRNA precursors that bypass Drosha processing

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The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila

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31 March 2020

Mammalian mirtron genes

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RNA and microRNAs in fragile X mental retardation

31 March 2020

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Inference of miRNA targets using evolutionary conservation and pathway analysis

31 March 2020

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The role of site accessibility in microRNA target recognition

31 March 2020

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The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR

31 March 2020

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

31 March 2020

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The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules

31 March 2020

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Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

31 March 2020

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Switching from repression to activation: microRNAs can up-regulate translation

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

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