DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs (Q27919703)

PubMed

PubMed publication ID

16914548

26 November 2016

title

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs (English)

1 reference

PubMed

PubMed publication ID

26 November 2016

0 references

Yunmei Ma

4

0 references

Ulrich Pannicke

2

0 references

Peter Kulesza

6

0 references

Michael R Lieber

8

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Ling-Chi Vicky Wang

5

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Klaus Schwarz

9

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Haihui Lu

3

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Ebrahim Zandi

7

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Doris Niewolik

Journal of Biological Chemistry

1

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language of work or name

English

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publication date

10 November 2006

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published in

1 reference

The mechanism and regulation of chromosomal V(D)J recombination

PubMed

volume

281

0 references

issue

45

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page(s)

33900-9

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cites work

1 reference

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V(D)J recombination: RAG proteins, repair factors, and regulation

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Human severe combined immune deficiency and DNA repair

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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Unraveling V(D)J recombination; insights into gene regulation

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The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

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The role of the non-homologous end-joining pathway in lymphocyte development

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

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Omenn syndrome due to ARTEMIS mutations

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DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

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Partial V(D)J recombination activity leads to Omenn syndrome

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

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Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.

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A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

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The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

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Functional and biochemical dissection of the structure-specific nuclease ARTEMIS

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The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination

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The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

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Transformation of mammalian cells with genes from procaryotes and eucaryotes

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In vitro nonhomologous DNA end joining system

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Autoinhibitory domains: modular effectors of cellular regulation

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin.

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DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

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The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Activation of DNA-dependent protein kinase by single-stranded DNA ends

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Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

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Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

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Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

21 January 2018

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DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

21 January 2018

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V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

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Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

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Identifiers

DOI

10.1074/JBC.M606023200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16914548

1 reference

Consolidated OpenCitations Corpus – April 2017