Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. (Q27937246)

PubMed

1 December 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

regulation of DNA helicase activity

16 December 2019

main subject

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1905774

negative regulation of DNA helicase activity

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1905775

positive regulation of DNA helicase activity

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1905776

Mini-chromosome maintenance complex protein 7 YBR202W

1 reference

MCM DNA helicase complex subunit MCM6 YGL201C

1 reference

MCM DNA helicase complex subunit MCM4 YPR019W

1 reference

MCM DNA helicase complex subunit MCM2 YBL023C

1 reference

author

Daniel L. Kaplan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Michael O'Donnell

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Megan J Davey

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

language of work or name

English

0 references

publication date

17 September 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

16 December 2019

published in

2 references

PubMed

1 December 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

issue

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

49171-49182

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:13679365%20AND%20SRC:MED&resulttype=core&format=json

Uninterrupted MCM2-7 function required for DNA replication fork progression

16 December 2019

cites work

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Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

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MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

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A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

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Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe

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Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity

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Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex

21 January 2018

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A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication

21 January 2018

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Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

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Helicases: amino acid sequence comparisons and structure-function relationships

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Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7

21 January 2018

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Mammalian Mcm2/4/6/7 complex forms a toroidal structure

21 January 2018

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SV40 large T antigen hexamer structure: domain organization and DNA-induced conformational changes

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The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings

21 January 2018

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Flexibility of the rings: structural asymmetry in the DnaB hexameric helicase

21 January 2018

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The primase active site is on the outside of the hexameric bacteriophage T7 gene 4 helicase-primase ring

21 January 2018

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A hexameric helicase encircles one DNA strand and excludes the other during DNA unwinding

21 January 2018

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Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases

21 January 2018

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The structure and function of MCM from archaeal M. Thermoautotrophicum

21 January 2018

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Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures

21 January 2018

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X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

21 January 2018

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Asymmetric interactions of hexameric bacteriophage T7 DNA helicase with the 5'- and 3'-tails of the forked DNA substrate.

21 January 2018

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The 3′-tail of a forked-duplex sterically determines whether one or two DNA strands pass through the central channel of a replication-fork helicase 1 1Edited by M. Gottesman

21 January 2018

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DnaB from Thermus aquaticus unwinds forked duplex DNA with an asymmetric tail length dependence

21 January 2018

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DnaB drives DNA branch migration and dislodges proteins while encircling two DNA strands.

21 January 2018

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Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

21 January 2018

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21 January 2018

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Replisome assembly reveals the basis for asymmetric function in leading and lagging strand replication.

21 January 2018

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Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication

21 January 2018

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21 January 2018

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A Dimer of Escherichia coli UvrD is the active form of the helicase in vitro

21 January 2018

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21 January 2018

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Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

21 January 2018

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21 January 2018

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